Evidence map›Paper›PMID 41648426›Full record

ArticlebioRxiv : the preprint server for biology2026

Behavioral state-dependent norepinephrine dynamics in the primary somatosensory and prefrontal cortices during tactile detection tasks.

Craig Kelley, Tim Lantin, Cody Slater, Marc Sorrentino, Kunpeng Yu, Bo Yuan, Michael Kann, Yuxiang Liu, Jung Soo Kim, Qi Wang

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Craig KelleyDepartment of Biomedical Engineering, Columbia University, ET 351, 500 W. 120 Street, New York, NY 10027.
Tim LantinDepartment of Biomedical Engineering, Columbia University, ET 351, 500 W. 120 Street, New York, NY 10027.
Cody SlaterDepartment of Biomedical Engineering, Columbia University, ET 351, 500 W. 120 Street, New York, NY 10027.
Marc SorrentinoDepartment of Biomedical Engineering, Columbia University, ET 351, 500 W. 120 Street, New York, NY 10027.
Kunpeng YuDepartment of Biomedical Engineering, Columbia University, ET 351, 500 W. 120 Street, New York, NY 10027.
Bo YuanDepartment of Biomedical Engineering, Columbia University, ET 351, 500 W. 120 Street, New York, NY 10027.
Michael KannDepartment of Biomedical Engineering, Columbia University, ET 351, 500 W. 120 Street, New York, NY 10027.
Yuxiang LiuDepartment of Biomedical Engineering, Columbia University, ET 351, 500 W. 120 Street, New York, NY 10027.
Jung Soo KimDepartment of Biomedical Engineering, Columbia University, ET 351, 500 W. 120 Street, New York, NY 10027.
Qi WangDepartment of Biomedical Engineering, Columbia University, ET 351, 500 W. 120 Street, New York, NY 10027.ORCID 0000-0001-8656-1439

Funding

The effects of long-term locus coeruleus stimulation on amyloid/tau pathology, synaptic plasticity, and memory during Alzheimer's disease progressionR01AG075114 · NIA · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Qi Wang · 2022 to 2026
$2.4M
Noradrenergic and Cholinergic Mechanisms Underlying Pupil-Linked Arousal Modulation of Thalamic Sensory ProcessingR01NS119813 · NINDS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI WANG, QI · 2021 to 2025
$2.2M
Cholinergic contribution to pupil-linked arousalR21MH125107 · NIMH · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI WANG, QI · 2021 to 2022
$446k
NIA NIH HHS R01 AG075114NIMH NIH HHS R21 MH125107NINDS NIH HHS R01 NS119813
6 · The paper itself

Abstract

Animals must integrate sensory information, ignore behaviorally irrelevant stimuli, and respond to behaviorally relevant stimuli to find food, find mates, avoid predators, and ultimately survive. In mammals, these goal-directed behaviors require the coordinated activity of many brain regions, including sensory and prefrontal cortices as well as neuromodulatory brainstem nuclei like the locus coeruleus (LC), which is the brain's primary source of norepinephrine. Norepinephrine resulting from LC activity and arousal indexed by pupil size exert strong influences on goal-directed behavior. We explored the relationships between pupil size, cortical noradrenergic dynamics, and behavior in a tactile signal detection task. We monitored pupil dynamics and fluorescent GRAB

Indexed as

GLM-HMM modelinglocus coeruleusNorepinephrinepupil-linked arousaltactile detection taskthe prefrontal cortexthe primary somatosensory cortex

Identifiers

PMID41648426
PMCPMC12871834

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.