Evidence map›Paper›PMID 41648568›Full record

ArticlebioRxiv : the preprint server for biology2026

Negative allosteric modulation of α5-GABA

Fernanda Daher, Caio T Fukushima, Erik A Ingebretsen, Jean M Bidlack, John R Atack, Mariana O Popa, Manoela V Fogaça

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Fernanda DaherDepartment of Pharmacology and Physiology, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, New York 14642, United States of America.
Caio T FukushimaDepartment of Pharmacology and Physiology, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, New York 14642, United States of America.
Erik A IngebretsenDepartment of Pharmacology and Physiology, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, New York 14642, United States of America.
Jean M BidlackDepartment of Pharmacology and Physiology, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, New York 14642, United States of America.
John R AtackMedicines Discovery Institute, Cardiff University, Park Place, CF10 3AT, Cardiff, Wales, United Kingdom.
Mariana O PopaMedicines Discovery Institute, Cardiff University, Park Place, CF10 3AT, Cardiff, Wales, United Kingdom.
Manoela V FogaçaDepartment of Pharmacology and Physiology, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, New York 14642, United States of America.ORCID 0000-0003-4212-7424

Funding

Cortical GABAergic mechanisms underlying rapid and sustained antidepressant responsesR00MH126098 · NIMH · UNIVERSITY OF ROCHESTER · PI FOGACA, MANOELA · 2023 to 2025
$730k
NIMH NIH HHS R00 MH126098
6 · The paper itself

Abstract

Chronic stress disrupts glutamatergic and GABAergic plasticity in the medial prefrontal cortex (mPFC), impairing circuit integration and contributing to the pathophysiology of stress-related disorders, such as Major Depressive Disorder (MDD). Rapid-acting antidepressants like ketamine can rapidly reverse these deficits, but its clinical use is limited by psychotomimetic side effects. Notably, the α5-GABA

Indexed as

BasmisanilGABAGlutamateKetamineNegative Allosteric ModulatorRapid-Acting Antidepressantα5-GABAA

Identifiers

PMID41648568
PMCPMC12871201

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.