Evidence map›Paper›PMID 41648569›Full record

ArticlebioRxiv : the preprint server for biology2026

Butyrate extends health and lifespan in mice with mitochondrial deficiency.

Enrique Gabandé-Rodríguez, Manuel M Gómez de Las Heras, Pablo Ramírez-Ruiz de Erenchun, Carolina Simó, Virginia García-Cañas, Naohiro Inohara, Inés Berenguer-López, Violeta Enríquez-Zarralanga, Álvaro Fernández-Almeida, Jorge Oller and 12 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

22 authors.

Enrique Gabandé-RodríguezTissue and Organ Homeostasis Program, Centro de Biología Molecular Severo Ochoa (CBM), Consejo Superior de Investigaciones Científicas (CSIC) - Universidad Autónoma de Madrid (UAM); Madrid, Spain.ORCID 0000-0002-9715-8714
Manuel M Gómez de Las HerasTissue and Organ Homeostasis Program, Centro de Biología Molecular Severo Ochoa (CBM), Consejo Superior de Investigaciones Científicas (CSIC) - Universidad Autónoma de Madrid (UAM); Madrid, Spain.ORCID 0000-0001-7447-694X
Pablo Ramírez-Ruiz de ErenchunTissue and Organ Homeostasis Program, Centro de Biología Molecular Severo Ochoa (CBM), Consejo Superior de Investigaciones Científicas (CSIC) - Universidad Autónoma de Madrid (UAM); Madrid, Spain.
Carolina SimóMolecular Nutrition and Metabolism, Institute of Food Science Research (CIAL), Consejo Superior de Investigaciones Científicas (CSIC) - Universidad Autónoma de Madrid (UAM); Madrid, Spain.ORCID 0000-0002-7140-0795
Virginia García-CañasMolecular Nutrition and Metabolism, Institute of Food Science Research (CIAL), Consejo Superior de Investigaciones Científicas (CSIC) - Universidad Autónoma de Madrid (UAM); Madrid, Spain.ORCID 0000-0001-6728-4325
Naohiro InoharaDepartment of Pathology and Rogel Cancer Center, University of Michigan Medical School; Ann Arbor, MI, USA.
Inés Berenguer-LópezPhysiological and Pathological Processes Program, Centro de Biología Molecular Severo Ochoa (CBM), Consejo Superior de Investigaciones Científicas (CSIC) - Universidad Autónoma de Madrid (UAM); Madrid, Spain.
Violeta Enríquez-ZarralangaPhysiological and Pathological Processes Program, Centro de Biología Molecular Severo Ochoa (CBM), Consejo Superior de Investigaciones Científicas (CSIC) - Universidad Autónoma de Madrid (UAM); Madrid, Spain.
Álvaro Fernández-AlmeidaTissue and Organ Homeostasis Program, Centro de Biología Molecular Severo Ochoa (CBM), Consejo Superior de Investigaciones Científicas (CSIC) - Universidad Autónoma de Madrid (UAM); Madrid, Spain.
Jorge OllerLaboratory of Vascular Pathology, IIS-Fundación Jiménez Díaz; Madrid, Spain.ORCID 0000-0002-2224-2954
Gonzalo Soto-HerederoTissue and Organ Homeostasis Program, Centro de Biología Molecular Severo Ochoa (CBM), Consejo Superior de Investigaciones Científicas (CSIC) - Universidad Autónoma de Madrid (UAM); Madrid, Spain.ORCID 0000-0001-8043-7314
Elisa CarrascoTissue and Organ Homeostasis Program, Centro de Biología Molecular Severo Ochoa (CBM), Consejo Superior de Investigaciones Científicas (CSIC) - Universidad Autónoma de Madrid (UAM); Madrid, Spain.ORCID 0000-0002-0817-1627
Sandra Delgado-PulidoTissue and Organ Homeostasis Program, Centro de Biología Molecular Severo Ochoa (CBM), Consejo Superior de Investigaciones Científicas (CSIC) - Universidad Autónoma de Madrid (UAM); Madrid, Spain.
José Ignacio Escrig-LarenaTissue and Organ Homeostasis Program, Centro de Biología Molecular Severo Ochoa (CBM), Consejo Superior de Investigaciones Científicas (CSIC) - Universidad Autónoma de Madrid (UAM); Madrid, Spain.ORCID 0000-0002-1538-8808
Isaac Francos-QuijornaTissue and Organ Homeostasis Program, Centro de Biología Molecular Severo Ochoa (CBM), Consejo Superior de Investigaciones Científicas (CSIC) - Universidad Autónoma de Madrid (UAM); Madrid, Spain.
Raquel Justo-MéndezCardiovascular Regeneration Program, Centro Nacional de Investigaciones Cardiovasculares (CNIC); Madrid, Spain.ORCID 0000-0002-7648-3550
Juan Francisco ArandaDepartment of Genetics, Physiology and Microbiology, Faculty of Biological Sciences, Complutense University of Madrid (UCM); Madrid, Spain.
Joanna PoultonNuffield Department of Women's and Reproductive Health, University of Oxford; United Kingdom.
Ana Victoria Lechuga-ViecoInstitute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Catalonia, Spain; ICREA, Catalan Institution for Research and Advanced Studies Barcelona; Barcelona, Catalonia, Spain.
José Antonio EnríquezCardiovascular Regeneration Program, Centro Nacional de Investigaciones Cardiovasculares (CNIC); Madrid, Spain.ORCID 0000-0002-3671-2961
Gabriel NúñezDepartment of Pathology and Rogel Cancer Center, University of Michigan Medical School; Ann Arbor, MI, USA.
María MittelbrunnTissue and Organ Homeostasis Program, Centro de Biología Molecular Severo Ochoa (CBM), Consejo Superior de Investigaciones Científicas (CSIC) - Universidad Autónoma de Madrid (UAM); Madrid, Spain.

Funding

Role of Immunity and the Microbiota in Enteropathogenic E. coli EradicationR01DK095782 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI NUNEZ, GABRIEL · 2013 to 2022
$3.6M
NIDDK NIH HHS R01 DK095782
6 · The paper itself

Abstract

Mitochondrial diseases progressively lead to multisystemic failure with treatment options remaining extremely limited. To investigate novel strategies that alleviate mitochondrial dysfunction, we have generated an ubiquitous and tamoxifen-inducible knockout mouse model of mitochondrial transcription factor A (TFAM), a nuclear-encoded protein involved in mitochondrial DNA (mtDNA) maintenance -

Indexed as

epigeneticsgut microbiotahistone acylationMitochondriamtDNA-mutatorshort-chain fatty acidsTFAM

Identifiers

PMID41648569
PMCPMC12871363

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.