ArticlebioRxiv : the preprint server for biology2026
Molecular basis of UV lesion binding and repair inhibition by ETS-family transcription factors.
Smitha Sivapragasam, J Ross Terrell, Markus W Germann, Marian F Laughery, Michaela E Everly, Shiva P Adhikari, Patrick J Hrdlicka, John J Wyrick, Gregory M K Poon
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
9 authors.
Smitha SivapragasamSchool of Molecular Biosciences, Washington State University, Pullman WA 99164.
J Ross TerrellDepartment of Chemistry, Georgia State University, Atlanta, GA 30303.
Markus W GermannDepartment of Chemistry, Georgia State University, Atlanta, GA 30303.
Marian F LaugherySchool of Molecular Biosciences, Washington State University, Pullman WA 99164.
Michaela E EverlyDepartment of Chemistry, University of Idaho, Moscow, ID 83844.
Shiva P AdhikariDepartment of Chemistry, University of Idaho, Moscow, ID 83844.
Patrick J HrdlickaDepartment of Chemistry, University of Idaho, Moscow, ID 83844.
John J WyrickSchool of Molecular Biosciences, Washington State University, Pullman WA 99164.
Funding
Genome-wide analysis of the formation and mutagenesis of atypical UV photoproducts in skin cancerR01ES032814 · NIEHS · WASHINGTON STATE UNIVERSITY · PI STEVEN A ROBERTS, John J Wyrick · 2021 to 2026
$5.8MRegulation of DNA Excision Repair in ChromatinR01ES028698 · NIEHS · WASHINGTON STATE UNIVERSITY · PI John J Wyrick · 2018 to 2026
$2.7MDirect chemical control of the hematopoietic master transcription factor PU.1R01HL155178 · NHLBI · GEORGIA STATE UNIVERSITY · PI POON, GREGORY MAN KAI · 2021 to 2023
$1.2MIdentifying recurrent driver mutations in skin cancers by targeted UV damage sequencingR21ES035139 · NIEHS · WASHINGTON STATE UNIVERSITY · PI WYRICK, JOHN J · 2023 to 2024
$449kThe role of Elf1 in transcription coupled-nucleotide excision repairR21ES035888 · NIEHS · WASHINGTON STATE UNIVERSITY · PI SELVAM, KATHIRESAN, WYRICK, JOHN J · 2024 to 2025
$438kProfiling the specificity of SPI1 and SPIB activity for drug discoveryR03TR004842 · NCATS · GEORGIA STATE UNIVERSITY · PI POON, GREGORY MAN KAI · 2025 to 2025
$156kNCATS NIH HHS R03 TR004842NHLBI NIH HHS R01 HL155178NIEHS NIH HHS R01 ES028698NIEHS NIH HHS R01 ES032814NIEHS NIH HHS R21 ES035139NIEHS NIH HHS R21 ES035888
6 · The paper itselfAbstract
Mutation hotspots in melanoma frequently occur at DNA binding sites of ETS-family transcription factors, as ETS factors stimulate the formation of UV-induced cyclobutane pyrimidine dimers (CPDs) while suppressing repair at ETS-bound DNA sites. To elucidate the molecular mechanism by which ETS factors bind to damaged DNA sites and inhibit repair, we investigated the binding of members from the three major classes of the ETS superfamily (Ets1, ELF1 and PU.1) to cognate DNA containing a
Indexed as
cyclobutane pyrimidine dimerDNA repair inhibitionELF1Ets1ETS transcription factorsPU.1
Identifiers
PMID41648613
PMCPMC12871226
What Socratic holds
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