ArticleFood science & nutrition2026
Causal Effect of Dietary Patterns on Cerebral Small Vessel Disease: A Mendelian Randomization Study.
Article in Food science & nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
While emerging observational evidence suggests associations between dietary factors and cerebral small vessel disease (CSVD), the causal nature of these relationships remains unestablished. This study employed a two-sample Mendelian randomization (MR) framework to investigate genetically predicted causal effects of dietary patterns on neuroimaging markers of CSVD. We utilized Genome-Wide Association Study (GWAS) summary statistics from European-ancestry cohorts for 32 dietary exposures and four CSVD phenotypes: white matter hyperintensities (WMH), lacunar strokes (LS), enlarged perivascular spaces (PVS), and brain microbleeds (BMB). Specifically, WMH volume, fractional anisotropy (FA), and mean diffusivity (MD) are indicators related to WMH. Genetic instruments (single-nucleotide polymorphisms, SNPs) were rigorously selected using genome-wide significance thresholds (
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