ArticleFrontiers in endocrinology2026
The MTHFR C677T genetic susceptibility and its role in risk prediction for type 2 diabetic nephropathy in Northern China.
Article in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Diabetic nephropathy is a diabetes-induced chronic kidney disease characterized by pathological changes that may involve the entire renal structure and can progress to end-stage renal disease, thereby substantially impairing patients' quality of life. The MTHFR C677T gene polymorphism has been closely associated with the development of diabetic nephropathy through its regulatory effect on homocysteine levels. Evidence suggests that both the MTHFR C677T genetic variant and other clinical or environmental risk factors may interactively contribute to disease susceptibility. This study investigated the genetic predisposition conferred by MTHFR C677T and its interaction with modifiable risk factors among patients with diabetic nephropathy in northern China, aiming to establish a region-specific risk prediction model for improved early identification and prevention. Material and methods: From January 2018 to 2024, a total of 397 patients with type 2 diabetes were selected from the Second Hospital of Shanxi Medical University. Among them, 153 cases were diagnosed as diabetic nephropathy group (DN group), and the remaining 244 cases were control group (N-DN group). The clinical data of these patients were extracted from electronic medical records. The biochemistry index, including homocysteine (Hcy) were collected from the hospital laboratory test system and the polymorphism of MTHFR C677T gene was analyzed by polymerase chain reaction (PCR) test. The risk prediction model of diabetic nephropathy was established by Logistic regression. Results: MTHFR C677T gene polymorphism was closely related to diabetic nephropathy. The proportion of 677TT genotype (57.52%) and the homocysteine concentration in DN group were significantly higher than those in N-DN group, and the circulating homocysteine concentration in 677TT genotype (17.29 ± 8.95 μmol/L) was significantly higher than that in 677CT genotype (13.08 ± 6.20 μmol/L) and 677CC genotype (12.65 ± 4.35 μmol/L) (P < 0.001). The carriers of MTHFR677CT and MTHFR677TT genotypes could increase 3.298-fold and 12.713-fold risk of having DN respectively compared with the carriers of 677CC genotype.In addition, the diabetic peripheralangiopathy, the diabetic retinopathy, triglyceride(TG), HOMA-IR, HCY(16-30μmol/L), HCY(>30μmol/L), Blood urea nitrogen(BUN), urinary microalbumin creatinine ratio (ACR) were independent risk factors for diabetic retinopathy (OR = 2.462, 4.572, 1.548, 1.133, 1.571,1.379,1.254,1.003). The above eight factors constitute the Nomogram risk prediction model of DN with good test performance and discriminant ability. Conclusion: MTHFR C677T genotype, Hcy, the diabetic peripheralangiopathy, the diabetic retinopathy, triglyceride(TG), HOMA-IR, Blood urea nitrogen(BUN), urinary microalbumin creatinine ratio (ACR)diabetic retinopathy were independent factors for diabetic nephropathy, which would help to identify the risk of diabetic nephropathy and provide the basis for the development of diabetic nephropathy control strategies and treatment measures.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.