Evidence map›Paper›PMID 41648725›Full record

SynthesisFrontiers in endocrinology2026

Clinical characteristics associated with somatic

Brendan R Dillon, Margaret Ruddy, Emily C McQuade, Shruti N Shah, Alberta Twi-Yeboah, Benjamin A Levinson, Nidhi Agrawal

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Pathogenesis of nonfamilial somatotroph adenomas.The Journal of clinical endocrinology and metabolism · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Brendan R DillonHolman Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, New York University Langone Health, New York, NY, United States.
Margaret RuddyHolman Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, New York University Langone Health, New York, NY, United States.
Emily C McQuadeDepartment of Medicine, New York University Langone Health, New York, NY, United States.
Shruti N ShahNew York University Grossman School of Medicine, New York, NY, United States.
Alberta Twi-YeboahDivision of Biostatistics, Department of Population Health, New York University Langone Health, New York, NY, United States.
Benjamin A LevinsonDivision of Biostatistics, Department of Population Health, New York University Langone Health, New York, NY, United States.
Nidhi AgrawalHolman Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, New York University Langone Health, New York, NY, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Acromegaly is a rare, insidious disease associated with significant morbidity and mortality usually caused by a growth hormone (GH)-secreting pituitary tumor. Somatic mutations in Methods: We conducted a structured review of the literature and meta-analysis to investigate the association of Results: We identified 55 publications that met our inclusion criteria, all observational in nature and most retrospective in design. Twenty-two patients with acromegaly at our institution underwent pituitary tumor resection followed by tumor somatic mutation analysis from 2022 to 2024. The aggregate prevalence of somatic Conclusions: Despite their high prevalence, Systematic Review Registration: https://www.crd.york.ac.uk/prospero/, identifier CRD420251107763.

Indexed as

AcromegalyChromograninsGrowth Hormone-Secreting Pituitary AdenomaGTP-Binding Protein alpha Subunits, GsMutationAdenomaHumansMalePituitary NeoplasmsPrognosisChromograninsGNAS protein, humanGTP-Binding Protein alpha Subunits, Gsacromegalyclinical characteristicsGNASpostoperative outcomessomatotroph tumors

Identifiers

PMID41648725
PMCPMC12867796

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.