Evidence map›Paper›PMID 41648729›Full record

ReviewFrontiers in aging2025

Age-related hearing loss and balance disorders: analysis of interactions and clinical implications in older persons. Systematic review and meta-analysis.

Andrea Frosolini, Leonardo Franz, Leonardo Calvanese, Valeria Caragli, Daniela Parrino, Cristoforo Fabbris, Giulio Badin, Michael Negrisolo, Roberta Cenedese, Lisa Doretto and 5 more

Abstract readReview
In one paragraph

Review in Frontiers in aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Andrea Frosolini *Maxillofacial Surgery Unit, Department of Medical Biotechnologies, University of Siena, Siena, Italy.
Leonardo Franz *Phoniatrics and Audiology Unit, Department of Neuroscience DNS, University of Padova, Treviso, Italy.
Leonardo CalvaneseENT Unit, Surgical Department, Ospedali Riuniti Padova Sud, Monselice-Padova, Italy.
Valeria CaragliDepartment of Medical and Surgical Sciences for Children and Adults, Otorhinolaryngology Unit, University of Modena and Reggio Emilia, Modena, Italy.
Daniela ParrinoDepartment of Otorhinolaryngology Head and Neck Surgery, ASST Sette Laghi, Ospedale di Circolo e Fondazione Macchi, Varese, Italy.
Cristoforo FabbrisENT Unit, Surgical Department, Ospedali Riuniti Padova Sud, Monselice-Padova, Italy.
Giulio BadinOtolaryngology Unit, Department of Neuroscience DNS, University of Padova, Padova, Italy.
Michael NegrisoloENT Unit, Surgical Department, Ospedali Riuniti Padova Sud, Monselice-Padova, Italy.
Roberta CenedesePhoniatrics and Audiology Unit, Department of Neuroscience DNS, University of Padova, Treviso, Italy.
Lisa DorettoPhoniatrics and Audiology Unit, Department of Neuroscience DNS, University of Padova, Treviso, Italy.
Giuseppe BresciaENT Unit, Surgical Department, Ospedali Riuniti Padova Sud, Monselice-Padova, Italy.
Cosimo de FilippisPhoniatrics and Audiology Unit, Department of Neuroscience DNS, University of Padova, Treviso, Italy.
Elisabetta GenoveseDepartment of Medical and Surgical Sciences for Children and Adults, Otorhinolaryngology Unit, University of Modena and Reggio Emilia, Modena, Italy.
Elisabetta ZanolettiOtolaryngology Unit, Department of Neuroscience DNS, University of Padova, Padova, Italy.
Gino MarioniPhoniatrics and Audiology Unit, Department of Neuroscience DNS, University of Padova, Treviso, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Age-related hearing loss (ARHL) frequently coexists with balance disorders in older persons, but the mechanisms and rehabilitative leverage of this association remain unsettled. We synthesized evidence on interactions between ARHL and vestibular/gait dysfunction, quantified mobility and fall outcomes, and appraised clinical implications for prevention. Methods: Following PRISMA and a registered PROSPERO protocol, we searched PubMed (MEDLINE), Scopus and Web of Science Core Collection. Inclusion required adults ≥65 years, ARHL and quantitative vestibular/balance outcomes. Forty studies met the criteria. Vestibular pooling was infeasible due to heterogeneous designs and metrics. In quantitative analysis, continuous outcomes were meta-analysed as standardized mean differences (SMD) (Hedges g) using random effects (REML) for ARHL-control contrasts and a fixed effect for within-participant Hearing Aid (HA) ON-OFF contrasts. For falls, we pooled Odds Ratio (OR) with REML. Results: Five out of seven studies linked ARHL to vestibular impairment. Across six studies, ARHL was associated with slower Timed Up to Go (SMD = -0.679), yet meta-regression showed systematic bias from age imbalance (-0.036 SMD per year older in HL), and the adjusted intercept was not significant. In three HA ON-OFF studies, static posturography improved with amplification (g = 0.459). The falls meta-analysis (k = 4; follow-up 12-60 months) showed higher fall odds with ARHL (OR = 1.55). Discussion: Age is a dominant driver of mobility, but ARHL contributes modifiable risk through sensory and cognitive-motor pathways. Consistent improvements with HA and converging gait data support integrating auditory rehabilitation-alongside vestibular/sensory-integration training-into multimodal fall-prevention strategies. Standardized protocols and age-balanced trials are priorities to refine effect estimates and clarify mechanisms.

Indexed as

age-related hearing lossbalance disorderscochlear implantfallshearing aidsolder persons

Identifiers

PMID41648729
PMCPMC12868133

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.