Evidence map›Paper›PMID 41649434›Full record

ArticleJACC. Clinical electrophysiology2026

Selectivity Filter Mutation in Na

Zoja Selimi, Mikhail Tarasov, Xiaolei Meng, Patrícia Dias, Bianca Moise, Haiyan Liu, Omer Cavus, Drew Nassal, Rengasayee Veeraraghavan, Przemysław B Radwański

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Clinical electrophysiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Intracellular Ionic Remodeling During Fetal Development of Hereditary Cardiomyopathy of the Hamster.Pathophysiology : the official journal of the International Society for Pathophysiology · 2026
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Zoja SelimiThe Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Division of Pharmaceutics and Pharmacology, College of Pharmacy, The Ohio State University, Columbus, Ohio, USA.
Mikhail TarasovThe Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Division of Pharmaceutics and Pharmacology, College of Pharmacy, The Ohio State University, Columbus, Ohio, USA.
Xiaolei MengThe Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Division of Pharmaceutics and Pharmacology, College of Pharmacy, The Ohio State University, Columbus, Ohio, USA.
Patrícia DiasThe Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Division of Pharmaceutics and Pharmacology, College of Pharmacy, The Ohio State University, Columbus, Ohio, USA.
Bianca MoiseThe Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Department of Biomedical Engineering, College of Engineering, The Ohio State University, Columbus, Ohio, USA.
Haiyan LiuThe Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Department of Physiology and Cell Biology, College of Medicine, The Ohio State University, Columbus, Ohio, USA.
Omer CavusThe Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Department of Physiology and Cell Biology, College of Medicine, The Ohio State University, Columbus, Ohio, USA.
Drew NassalThe Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Department of Physiology and Cell Biology, College of Medicine, The Ohio State University, Columbus, Ohio, USA.
Rengasayee VeeraraghavanThe Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Department of Biomedical Engineering, College of Engineering, The Ohio State University, Columbus, Ohio, USA; Department of Physiology and Cell Biology, College of Medicine, The Ohio State University, Columbus, Ohio, USA.
Przemysław B RadwańskiThe Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Division of Pharmaceutics and Pharmacology, College of Pharmacy, The Ohio State University, Columbus, Ohio, USA; Department of Physiology and Cell Biology, College of Medicine, The Ohio State University, Columbus, Ohio, USA. Electronic address: radwanski.2@osu.edu.

Funding

Regulation and dysregulation of sodium channels by by calmodulinR01HL155378 · NHLBI · OHIO STATE UNIVERSITY · PI RADWANSKI, PRZEMYSLAW · 2021 to 2025
$2.5M
Targeting Vascular Leak and Intercalated Disk Nanodomains to Prevent Atrial FibrillationR01HL148736 · NHLBI · OHIO STATE UNIVERSITY · PI VEERARAGHAVAN, RENGASAYEE · 2020 to 2024
$2.2M
Defining Novel Mechanisms of Sudden Death in Dravet Syndrome: Dysregulation of Sodium Channels in the HeartR01NS121234 · NINDS · OHIO STATE UNIVERSITY · PI Przemyslaw Radwanski · 2022 to 2026
$2.1M
NHLBI NIH HHS R01 HL148736NHLBI NIH HHS R01 HL155378NINDS NIH HHS R01 NS121234
6 · The paper itself

Abstract

backgroundLoss-of-function mutations in the SCN5A gene, which encodes for the predominant cardiac Na

objectivesIn this study, we generated a mouse heterozygous for Na

methodsPatch clamp electrophysiology studies were conducted in Chinese hamster ovary cells expressing the DEEA variant, along with immunolabeling, voltage optical mapping, and in vivo electrocardiography studies in a DEEA murine model of BrS.

resultsA heterologous expression system and isolated cardiomyocytes revealed lower current density and unchanged Na

conclusionsOverall, to our knowledge, we provide the first mechanistic insight into the proarrhythmic consequences of a functionally deficient BrS mutation in Na

Indexed as

NAV1.5 Voltage-Gated Sodium ChannelTachycardia, VentricularAnimalsBrugada SyndromeCHO CellsCricetinaeCricetulusDisease Models, AnimalElectrocardiographyFemaleMaleMiceMutation, MissenseMyocytes, CardiacNAV1.5 Voltage-Gated Sodium ChannelScn5a protein, mousearrhythmiaBrugada syndromeloss-of-functionselectivity filtersodium channels

Identifiers

PMID41649434
PMCPMC12952376

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.