Evidence map›Paper›PMID 41649786›Full record

ArticleObesity surgery2026

Prospective Study of Appetitive Sensations after Metabolic and Bariatric Surgery Compared with Low-Calorie Diet.

Lelia Tolbert, Sarah Borden, Jamie Leskowitz, Rajasekhar Ramakrishnan, Tirissa Reid, Abraham Krikhely, Marc Bessler, Judith Korner

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Obesity surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lelia TolbertColumbia University, Barnard College, New York, USA. llt2132@alum.barnard.edu.
Sarah BordenDepartment of Medicine, Columbia University Vagelos College of Physicians & Surgeons, New York, USA.
Jamie LeskowitzDepartment of Medicine, Columbia University Vagelos College of Physicians & Surgeons, New York, USA.
Rajasekhar RamakrishnanDepartment of Pediatrics, Columbia University Vagelos College of Physicians & Surgeons, New York, USA.
Tirissa ReidDepartment of Medicine, Columbia University Vagelos College of Physicians & Surgeons, New York, USA.
Abraham KrikhelyDepartment of Surgery, Columbia University Vagelos College of Physicians & Surgeons, New York, USA.
Marc BesslerDepartment of Surgery, Columbia University Vagelos College of Physicians & Surgeons, New York, USA.
Judith KornerDepartment of Medicine, Columbia University Vagelos College of Physicians & Surgeons, New York, USA. jk181@cumc.columbia.edu.

Funding

Clinical and Translational Science AwardUL1TR001873 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI REILLY, MUREDACH P · 2016 to 2025
$99.0M
NCATS NIH HHS UL1TR001873NIDDK NIH HHS DK072011
6 · The paper itself

Abstract

introductionMetabolic and bariatric surgery (MBS) causes greater weight loss (WL) compared with low-calorie diet (LCD) that may be due to changes in appetite and gut hormones. The objective of this study was to quantify appetitive sensations in individuals who underwent LCD or MBS at equivalent weight loss (T2) and at one year (T3).

methodsVisual analog scales (VAS) and the food craving inventory were used to assess appetite. Glucagon-like peptid-1 (GLP-1) levels were quantified by ELISA.

resultsParticipants available for both T1 and T2 were as follows: LCD (n = 15), surgery (n = 24). By T3, LCD (n = 12) and surgery (n = 15). At T2, percent total WL (%TWL) was similar between LCD vs surgery (14.9% vs 14.6%; p = 0.94). At T3, there was greater %TWL after surgery compared with LCD (30.2% vs 14.6%; p < 0.0001). At T2, there was a significant increase in postprandial fullness and decreases in hunger and prospective eating only after surgery. Cravings decreased in both groups at T2 but remained decreased at T3 only after surgery. There was almost a two-fold increase from T1 to T2 in postprandial GLP-1 after surgery (p < 0.0001) that correlated with the increase in fullness (r = 0.69; p = 0.038); no change was noted after LCD (p = 0.34).

conclusionsAfter equivalent WL, MBS results in favorable changes in appetitive sensations and GLP-1 levels compared with LCD. Such changes may support the ability to achieve greater reduction in body weight after MBS.

Indexed as

AppetiteBariatric SurgeryCaloric RestrictionDiet, ReducingObesity, MorbidAdultCravingFemaleGlucagon-Like Peptide 1HumansHungerMaleMiddle AgedPostprandial PeriodProspective StudiesWeight LossGlucagon-Like Peptide 1

Identifiers

PMID41649786
PMCPMC13222243

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.