Trial reportPloS one2026
Protocol: Effects of midazolam on postoperative delirium in elderly patients undergoing spinal surgery: A randomized, double-blind, placebo-controlled non-inferiority trial.
Trial report in PloS one, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionPostoperative delirium (POD) is a common complication in elderly patients, linked to prolonged hospitalization, increased morbidities, and mortality. Midazolam, a widely used perioperative benzodiazepine, has controversial associations with POD: some studies suggest risks, while others find no significant link, but evidence quality remains low. This trial explores whether midazolam is non-inferior to placebo in POD incidence among elderly spinal surgery patients. METHODS AND ANALYSIS: A single-center, randomized, double-blind, placebo-controlled non-inferiority trial at Ningbo No. 6 Hospital, China, enrolling 692 elderly patients undergoing elective spinal surgery under general anesthesia. Exclusions include emergency surgery, long-term preoperative benzodiazepine use, and severe cognitive impairment. Participants are randomized 1:1 to receive midazolam (2 mg) or placebo (saline) during induction, via sealed envelopes. Blinding is maintained except for the preparing nurse. Primary outcome: POD incidence assessed by Evaluation tool: Confusion Assessment Method (CAM) on postoperative days 1-3. Secondary outcomes include POD details, agitation (Richmond scale), pain (NRS), lab indicators, hospital stay, and complications.
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