Evidence map›Paper›PMID 41650227›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Neurotensin in the extended amygdala maintains wakefulness in novel environments.

Chi Jung Hung, Shuhei Ueda, Sheikh Mizanur Rahaman, Mikiyasu Yamamoto, Jiahui Li, Noriaki Fukatsu, Haruhiko Bito, Hiroshi Yamaguchi, Akihiro Yamanaka, Sayaka Takemoto-Kimura and 1 more

Abstract read
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In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Chi Jung Hung *Stress Recognition and Response, Research Institute of Environmental Medicine, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan.ORCID 0000-0002-1169-7953
Shuhei Ueda *Department of Neuroscience, Research Institute of Environmental Medicine, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan.ORCID 0000-0001-8107-8608
Sheikh Mizanur RahamanStress Recognition and Response, Research Institute of Environmental Medicine, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan.ORCID 0009-0007-6470-8357
Mikiyasu YamamotoDepartment of Neuroscience, Research Institute of Environmental Medicine, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan.ORCID 0009-0005-9302-7679
Jiahui LiStress Recognition and Response, Research Institute of Environmental Medicine, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan.
Noriaki FukatsuDepartment of Anatomy and Molecular Cell Biology, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan.ORCID 0000-0002-0206-0256
Haruhiko BitoDepartment of Neurochemistry, The University of Tokyo Graduate School of Medicine, Bunkyo-ku, Tokyo 113-0033, Japan.ORCID 0000-0001-6315-9594
Hiroshi YamaguchiDivision of Multicellular Circuit Dynamics, National Institute for Physiological Sciences, Okazaki 444-8585, Japan.
Akihiro YamanakaChinese Institute for Brain Research, Beijing 102206, China.ORCID 0000-0001-6099-7306
Sayaka Takemoto-KimuraDepartment of Neuroscience, Research Institute of Environmental Medicine, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan.ORCID 0000-0002-2190-3191
Daisuke OnoStress Recognition and Response, Research Institute of Environmental Medicine, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan.ORCID 0000-0001-5967-2002

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Animals remain awake in unfamiliar environments to assess potential safety threats, a process involving changes in neuronal activity within sleep-wake regulatory brain regions. However, the specific circuits and neurotransmitters involved remain poorly understood. Here, we show that neurotensin (NTS) peptides in corticotropin-releasing factor (CRF) neurons of the lateral part of the interstitial nucleus of the posterior limb of the anterior commissure (IPACL) play a key role in maintaining wakefulness in response to environmental changes. Activation of IPACL

Indexed as

AmygdalaNeurotensinWakefulnessAnimalsCorticotropin-Releasing HormoneEnvironmentMiceNeuronsSubstantia NigraCorticotropin-Releasing HormoneNeurotensininterstitial nucleus of the posterior limb of the anterior commissureneurotensinnovel environmentssubstantia nigrawakefulness

Identifiers

PMID41650227
PMCPMC12890897

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.