Evidence map›Paper›PMID 41650956›Full record

ArticleDevelopmental cell2026

Bmp9 regulates Notch signaling and the temporal dynamics of angiogenesis via Lunatic Fringe.

Tommaso Ristori, Raphael Thuret, Erika Hooker, Peter Quicke, Sami Sanlidag, Kevin Lanthier, Kalonji Ntumba, Irene M Aspalter, Marina Uroz, Cecilia M Sahlgren and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Developmental cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. YAP/TAZ drives Notch and angiogenesis mechanoregulation in silico.NPJ systems biology and applications · 2024
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Tommaso RistoriDepartment of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, 5612 AZ, the Netherlands; Institute for Complex Molecular Systems (ICMS), Eindhoven University of Technology, Eindhoven, 5612 AZ, the Netherlands; Biological Design Center and Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA. Electronic address: t.ristori@tue.nl.
Raphael ThuretFaculty of Biology, Medicine & Health, The University of Manchester, Manchester M13 9PT, United Kingdom.
Erika HookerMaisonneuve-Rosemont Hospital, Montreal, QC H1T 2M4, Canada.
Peter QuickeThe Francis Crick Institute, London NW1 1AT, UK.
Sami SanlidagFaculty of Science and Engineering, Åbo Akademi University, 20520 Turku, Finland; InFLAMES research flagship center, Åbo Akademi University and University of FI-20520 Turku, Finland; Turku Bioscience Centre, Åbo Akademi University and University of Turku, 20520 Turku, Finland.
Kevin LanthierMaisonneuve-Rosemont Hospital, Montreal, QC H1T 2M4, Canada; Department of Ophthalmology, Université de Montréal, Montreal, QC H3C 3J7, Canada.
Kalonji NtumbaMaisonneuve-Rosemont Hospital, Montreal, QC H1T 2M4, Canada.
Irene M AspalterThe Francis Crick Institute, London NW1 1AT, UK.
Marina UrozBiological Design Center and Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA.
Cecilia M SahlgrenFaculty of Science and Engineering, Åbo Akademi University, 20520 Turku, Finland; InFLAMES research flagship center, Åbo Akademi University and University of FI-20520 Turku, Finland; Turku Bioscience Centre, Åbo Akademi University and University of Turku, 20520 Turku, Finland.
Shane P HerbertFaculty of Biology, Medicine & Health, The University of Manchester, Manchester M13 9PT, United Kingdom.
Christopher S ChenBiological Design Center and Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA.
Bruno LarrivéeMaisonneuve-Rosemont Hospital, Montreal, QC H1T 2M4, Canada; Department of Ophthalmology, Université de Montréal, Montreal, QC H3C 3J7, Canada. Electronic address: bruno.larrivee@umontreal.ca.
Katie BentleyThe Francis Crick Institute, London NW1 1AT, UK; Department of Informatics, King's College London, London WC2B 4BG, UK. Electronic address: katie.bentley@crick.ac.uk.

Funding

REGULATION OF ANGIOGENESIS BY MICROENVIRONMENTAL CUESR01EB000262 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI CHEN, CHRISTOPHER S · 2002 to 2023
$6.2M
Notch signaling and adhesion regulationR01HL147585 · NHLBI · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI CHEN, CHRISTOPHER S · 2019 to 2022
$1.6M
NHLBI NIH HHS R01 HL147585NIBIB NIH HHS R01 EB000262Wellcome Trust FC001751
6 · The paper itself

Abstract

Sprouting angiogenesis and blood vessel stabilization require precise coordination between endothelial cells (ECs) and pericytes. Bone Morphogenic Protein 9 (Bmp9), whose signaling through activin receptor-like kinase 1 (Alk1) is dysregulated in several diseases, was thought to regulate these processes by independently activating Notch target genes in an additive fashion with canonical Notch signaling. Here, through predictive computational modeling validated in mice, zebrafish, and human cell lines, we uncover that Bmp9 enhances Notch activity synergistically by upregulating Lunatic Fringe (Lfng) in ECs. Specifically, Bmp9-induced Lfng enhances Notch receptor activation, most strongly when Delta-like ligand 4 (Dll4) is also present. This Lfng regulation alters vessel branching by modulating the timing of EC phenotype selection and rearrangement during angiogenesis. Lfng also contributes to pericyte-driven vessel stabilization by mediating Jagged1 upregulation in Bmp9-stimulated ECs. In summary, Bmp9-upregulated Lfng enhances Dll4-Notch1 signaling in ECs and Jag1-Notch3 activation in pericytes, shaping angiogenic sprouting and stabilization outcomes.

Indexed as

AngiogenesisGlycosyltransferasesGrowth Differentiation Factor 2Growth Differentiation FactorsNeovascularization, PhysiologicReceptors, NotchSignal TransductionAdaptor Proteins, Signal TransducingAnimalsCalcium-Binding ProteinsEndothelial CellsHumansHuman Umbilical Vein Endothelial CellsIntracellular Signaling Peptides and ProteinsJagged-1 ProteinMembrane ProteinsAdaptor Proteins, Signal TransducingCalcium-Binding ProteinsDLL4 protein, humanGDF2 protein, humanGlycosyltransferasesGrowth Differentiation Factor 2Growth Differentiation FactorsIntracellular Signaling Peptides and ProteinsJAG1 protein, humanJagged-1 ProteinLFNG protein, humanLfng protein, mouseMembrane ProteinsReceptors, NotchZebrafish ProteinsActivin receptor-like kinase 1angiogenesisBone Morphogenic Protein 9computational modelingendothelial cellshereditary hemorrhagic telangiectasiaLunatic FringeNotch signalingpericytes

Identifiers

PMID41650956
PMCPMC13407922

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.