Evidence map›Paper›PMID 41651428›Full record

ReviewThe Journal of biological chemistry2026

Cell entry mechanisms of porcine enteric coronaviruses.

Yiping Wang, Fei Zhao, Qin Zhao, Senyan Du, Yiping Wen, Rui Wu, Sanjie Cao, Feng Cong, Xiaobo Huang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The Journal of biological chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yiping WangDepartment of Preventive Veterinary Medicine, Research Center for Swine Diseases, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China; Agricultural Animal Diseases and Veterinary Public Health Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, China; Engineering Research Center of Southwest Animal Disease Prevention and Control Technology of Ministry of Education, Sichuan Agricultural University, Chengdu, China; Key Laboratory of Agricultural Bioinformatics of Ministry of Education, Sichuan Agricultural University, Chengdu, China. Electronic address: yipingwang@sicau.edu.cn.
Fei ZhaoDepartment of Preventive Veterinary Medicine, Research Center for Swine Diseases, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
Qin ZhaoDepartment of Preventive Veterinary Medicine, Research Center for Swine Diseases, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China; Agricultural Animal Diseases and Veterinary Public Health Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, China; Engineering Research Center of Southwest Animal Disease Prevention and Control Technology of Ministry of Education, Sichuan Agricultural University, Chengdu, China.
Senyan DuDepartment of Preventive Veterinary Medicine, Research Center for Swine Diseases, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China; Agricultural Animal Diseases and Veterinary Public Health Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, China; Engineering Research Center of Southwest Animal Disease Prevention and Control Technology of Ministry of Education, Sichuan Agricultural University, Chengdu, China.
Yiping WenDepartment of Preventive Veterinary Medicine, Research Center for Swine Diseases, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China; Agricultural Animal Diseases and Veterinary Public Health Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, China; Engineering Research Center of Southwest Animal Disease Prevention and Control Technology of Ministry of Education, Sichuan Agricultural University, Chengdu, China.
Rui WuDepartment of Preventive Veterinary Medicine, Research Center for Swine Diseases, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China; Agricultural Animal Diseases and Veterinary Public Health Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, China; Engineering Research Center of Southwest Animal Disease Prevention and Control Technology of Ministry of Education, Sichuan Agricultural University, Chengdu, China.
Sanjie CaoDepartment of Preventive Veterinary Medicine, Research Center for Swine Diseases, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China; Agricultural Animal Diseases and Veterinary Public Health Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, China; Engineering Research Center of Southwest Animal Disease Prevention and Control Technology of Ministry of Education, Sichuan Agricultural University, Chengdu, China.
Feng CongCollege of Animal Science & Technology, Zhongkai University of Agriculture and Engineering, Guangzhou, China. Electronic address: 397020703@qq.com.
Xiaobo HuangDepartment of Preventive Veterinary Medicine, Research Center for Swine Diseases, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China; Agricultural Animal Diseases and Veterinary Public Health Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, China; Engineering Research Center of Southwest Animal Disease Prevention and Control Technology of Ministry of Education, Sichuan Agricultural University, Chengdu, China. Electronic address: rsghb110@126.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Porcine enteric coronaviruses, including transmissible gastroenteritis virus (TGEV), porcine epidemic diarrhea virus (PEDV), swine acute diarrhea syndrome coronavirus (SADS-CoV), and porcine deltacoronavirus (PDCoV), cause severe watery diarrhea, vomiting, dehydration, and high mortality in piglets, leading to enormous economic losses in the swine industry worldwide. They have the capability to infect a variety of cell lines from pigs, humans, and other animals, with high risks of interspecies transmission and potential threats to public health. These viruses employ their spike glycoproteins to engage with various receptors, coreceptors, cofactors, and other host factors that further mediate membrane fusion to accomplish the entry process. This review summarizes the recent findings regarding the pathways, receptors, coreceptors, cofactors, and other host factors utilized by TGEV, PEDV, SADS-CoV, and PDCoV for cellular entry. Several important targets for antiviral therapeutics and some key aspects of the entry process for these viruses that await discovery are highlighted. A comprehensive understanding of the entry mechanisms of porcine enteric coronaviruses will provide new insight into the development of novel antiviral therapeutic strategies.

Indexed as

CoronavirusCoronavirus InfectionsSwine DiseasesVirus InternalizationAlphacoronavirusAnimalsDeltacoronavirusHumansPorcine epidemic diarrhea virusSwineTransmissible gastroenteritis virusPDCoVPEDVporcine enteric coronavirusesSADS-CoVTGEVvirus entry

Identifiers

PMID41651428
PMCPMC12961333

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.