Evidence map›Paper›PMID 41651601›Full record

ReviewClinics in chest medicine2026

Immunology of Sepsis.

Eric D Morrell, Carmen Mikacenic

Abstract readReview
In one paragraph

Review in Clinics in chest medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Eric D MorrellDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of Washington, Harborview Medical Center, Box 359640, 325 9th Avenue, Seattle, WA 98104, USA; Veterans Affairs Puget Sound Health Care System, S-111-Pulmonary, 1660 S. Columbian Way, Seattle, WA 98108, USA. Electronic address: edmorrel@uw.edu.
Carmen MikacenicCenter for Translational Immunology, Benaroya Research Institute, 1201 9th Avenue, Seattle, WA 98101, USA.

Funding

Technology Development Project - Increasing the complexity of ex vivo human airway models for studying immune response to viral infectionU19AI142733 · NIAID · JACKSON LABORATORY · PI Anna Karolina Palucka · 2019 to 2026
$23.1M
Systems Immunology profiling of respiratory viral infections in vulnerable populationsU19AI167891 · NIAID · BENAROYA RESEARCH INST AT VIRGINIA MASON · PI Erik Wambre · 2022 to 2026
$14.0M
Immune Checkpoints in Acute Respiratory Distress Syndrome (IC-ARDS)R01HL149676 · NHLBI · BENAROYA RESEARCH INST AT VIRGINIA MASON · PI MIKACENIC, CARMEN R · 2020 to 2024
$3.0M
Molecular characterization of pulmonary edema: a window to an injured lungR01HL152083 · NHLBI · STANFORD UNIVERSITY · PI ROGERS, ANGELA J · 2020 to 2024
$2.9M
Alveolar macrophage subset ontogeny and differentiation during ARDSR01HL169265 · NHLBI · UNIVERSITY OF WASHINGTON · PI Eric Douglas Morrell · 2024 to 2026
$2.1M
NHLBI NIH HHS R01 HL149676NHLBI NIH HHS R01 HL152083NHLBI NIH HHS R01 HL169265NIAID NIH HHS U19 AI142733NIAID NIH HHS U19 AI167891
6 · The paper itself

Abstract

Sepsis-related immune dysregulation occurs in three overlapping phases, including pathogen recognition, inflammation, and immune paralysis. There are many immune cells that underlie these three phases, with the most well-studied being epithelial cells, neutrophils, monocytes, macrophages, and T cells. These cells regulate multiple downstream mediators, such as cytokines and chemokines, that can be measured and used as immunologic biomarkers. Past failures in sepsis immune-modulating treatment trials have likely resulted from the inclusion of patients meeting sepsis clinical criteria but who do not sufficiently express the immunologic target under investigation. More precise approaches to trial designs may uncover effective immune-modulating therapies.

Indexed as

SepsisCytokinesHumansMacrophagesMonocytesNeutrophilsT-LymphocytesCytokinesEpithelial cellsMacrophagesMonocytesNeutrophilsSepsisT cells

Identifiers

PMID41651601
PMCPMC13476014

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.