Evidence map›Paper›PMID 41651696›Full record

Observational studyNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics2026

Revisiting elevated HDL cholesterol, cerebral hemodynamic improvement in asymptomatic carotid artery disease: A longitudinal

Yorito Hattori, Soichro Abe, Yoshinori Kakino, Yuriko Nakaoku, Soshiro Ogata, Kunihiro Nishimura, Hidehiro Iida, Masafumi Ihara

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yorito HattoriDepartment of Neurology, National Cerebral and Cardiovascular Center, Suita, Japan; Department of Preemptive Medicine for Dementia, National Cerebral and Cardiovascular Center, Suita, Japan. Electronic address: yoh2019@ncvc.go.jp.
Soichro AbeDepartment of Neurology, National Cerebral and Cardiovascular Center, Suita, Japan.
Yoshinori KakinoDepartment of Neurology, National Cerebral and Cardiovascular Center, Suita, Japan.
Yuriko NakaokuDepartment of Preventive Medicine and Epidemiology, National Cerebral and Cardiovascular Center, Suita, Japan.
Soshiro OgataDepartment of Preventive Medicine and Epidemiology, National Cerebral and Cardiovascular Center, Suita, Japan.
Kunihiro NishimuraDepartment of Preventive Medicine and Epidemiology, National Cerebral and Cardiovascular Center, Suita, Japan.
Hidehiro IidaTurku PET Centre, University of Turku and Turku General Hospital, Turku, Finland.
Masafumi IharaDepartment of Neurology, National Cerebral and Cardiovascular Center, Suita, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Interventional trials with high-density lipoprotein cholesterol (HDL-C)-raising drugs have generally failed to demonstrate a beneficial effect on cardiovascular outcomes, although low HDL-C levels confer the risk of cerebrocardiovascular diseases. Previous experimental studies indicate that HDL-C promotes angiogenesis/arteriogenesis. Therefore, we aimed to clinically investigate whether high blood HDL-C levels could clinically predict cerebral hemodynamic improvements in patients with asymptomatic carotid artery stenosis/occlusion showing cerebral hypoperfusion. This longitudinal retrospective observational study included a total of 66 hemispheres governed by asymptomatic carotid artery stenosis/occlusion in patients who underwent 2-time multi-parametric

Indexed as

Carotid Artery DiseasesCarotid StenosisCerebrovascular CirculationCholesterol, HDLHemodynamicsAgedFemaleHumansLongitudinal StudiesMaleMiddle AgedOxygen RadioisotopesPositron-Emission TomographyRetrospective StudiesCholesterol, HDLOxygen-15Oxygen Radioisotopes(15)O-gas PETCarotid artery occlusionCarotid artery stenosisCerebral blood flowHigh-density lipoprotein cholesterol

Identifiers

PMID41651696
PMCPMC12976483

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.