Evidence map›Paper›PMID 41651994›Full record

ArticleCommunications biology2026

Sleep deprivation disrupts lacrimal gland homeostasis via hypothalamic-pituitary-adrenal axis and gut dysbiosis in mice.

Shenzhen Huang, Shufan Yu, Wenxiao Zhang, Di Qi, Xiaoting Pei, Dingli Lu, Mengru Ba, Shuting Xuan, Duliurui Huang, Jingwen Yang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Shenzhen HuangDepartment of Ophthalmology, People's Hospital of Henan University, Henan Provincial People's Hospital, Zhengzhou, China. huangshenzhen@zzu.edu.cn.ORCID http://orcid.org/0000-0002-2711-146X
Shufan YuDepartment of Ophthalmology, People's Hospital of Henan University, Henan Provincial People's Hospital, Zhengzhou, China.
Wenxiao ZhangDepartment of Ophthalmology, People's Hospital of Zhengzhou University, Henan Provincial People's Hospital, Zhengzhou, China.
Di QiHenan Key Laboratory of Ophthalmology and Visual Science, Henan Eye Hospital, People's Hospital of Henan University, People's Hospital of Zhengzhou University, Henan Provincial People's Hospital, Zhengzhou, China.
Xiaoting PeiHenan Key Laboratory of Ophthalmology and Visual Science, Henan Eye Hospital, People's Hospital of Henan University, People's Hospital of Zhengzhou University, Henan Provincial People's Hospital, Zhengzhou, China.
Dingli LuHenan Key Laboratory of Ophthalmology and Visual Science, Henan Eye Hospital, People's Hospital of Henan University, People's Hospital of Zhengzhou University, Henan Provincial People's Hospital, Zhengzhou, China.
Mengru BaDepartment of Ophthalmology, People's Hospital of Zhengzhou University, Henan Provincial People's Hospital, Zhengzhou, China.
Shuting XuanDepartment of Ophthalmology, People's Hospital of Henan University, Henan Provincial People's Hospital, Zhengzhou, China.
Duliurui HuangDepartment of Ophthalmology, People's Hospital of Zhengzhou University, Henan Provincial People's Hospital, Zhengzhou, China.
Jingwen YangHenan Key Laboratory of Ophthalmology and Visual Science, Henan Eye Hospital, People's Hospital of Henan University, People's Hospital of Zhengzhou University, Henan Provincial People's Hospital, Zhengzhou, China.
Zhijie LiHenan Key Laboratory of Ophthalmology and Visual Science, Henan Eye Hospital, People's Hospital of Henan University, People's Hospital of Zhengzhou University, Henan Provincial People's Hospital, Zhengzhou, China. tzhijieli@jnu.edu.cn.ORCID http://orcid.org/0000-0002-3186-144X

Funding

National Natural Science Foundation of China (National Science Foundation of China) 82101089
6 · The paper itself

Abstract

Sleep deprivation (SD) disrupts systemic homeostasis, but how it drives ocular surface disease remains unclear. Using a male mouse SD model, we show that chronic SD activates the hypothalamic-pituitary-adrenal (HPA) axis, elevates corticosterone, alters gut microbiota, and depletes short-chain fatty acids (SCFAs). These alterations coincide with lacrimal gland atrophy, reduced tear secretion, and increased CD4⁺/CD8⁺ T cell infiltration, accompanied by activation of IL-17-associated inflammatory pathways. Pharmacological inhibition of glucocorticoid synthesis with metyrapone preserves lacrimal gland structure and function while attenuating immune activation. Microbiome-directed interventions, including SCFA supplementation and fecal microbiota transplantation, rebalance gut communities, suppress pro-inflammatory T cell responses, and maintain lacrimal gland homeostasis. Transcriptomic and immunohistochemical analyses further reveal that all three interventions converge on the downregulation of IL-17 signaling. Collectively, these findings establish an HPA-gut microbiome-lacrimal gland axis that links neuroendocrine stress to microbial dysbiosis and ocular inflammation, and they suggest therapeutic strategies for SD-associated lacrimal gland dysfunction.

Indexed as

DysbiosisGastrointestinal MicrobiomeHomeostasisHypothalamo-Hypophyseal SystemLacrimal ApparatusPituitary-Adrenal SystemSleep DeprivationAnimalsInterleukin-17MaleMiceMice, Inbred C57BLInterleukin-17

Identifiers

PMID41651994
PMCPMC12987963

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.