Evidence map›Paper›PMID 41652207›Full record

ArticleJournal of gastroenterology2026

Intestinal obstruction impairs the antitumor function of hepatic natural killer cells against colorectal cancer.

Kouki Imaoka, Masahiro Ohira, Takuya Yano, Tomoaki Bekki, Yuki Imaoka, Ryosuke Nakano, Seiichi Shimizu, Manabu Shimomura, Yuka Tanaka, Tsuyoshi Kobayashi and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of gastroenterology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Kouki ImaokaDepartment of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
Masahiro OhiraDepartment of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan. mohira@hiroshima-u.ac.jp.ORCID 0000-0002-5433-5303
Takuya YanoDepartment of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
Tomoaki BekkiDepartment of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
Yuki ImaokaDepartment of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
Ryosuke NakanoDepartment of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
Seiichi ShimizuDepartment of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
Manabu ShimomuraDepartment of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
Yuka TanakaDepartment of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
Tsuyoshi KobayashiDepartment of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
Hideki OhdanDepartment of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis study aimed to investigate the impact of intestinal obstruction (IO) caused by colorectal cancer (CRC) on the cancer prognosis and recurrence patterns. We analyzed recurrence patterns in patients with stage II-III CRC and employed a murine model to elucidate the effects of IO on hepatic immunity.

methodsWe examined the clinical outcomes of CRC patients with IO and utilized a murine IO model to assess alterations in hepatic immunity, focusing on natural killer (NK) cell function.

resultsIO was significantly associated with poor prognosis and an increased incidence of liver metastases. In the murine model, IO induced hepatic inflammation and impaired the antitumor activity of liver-resident NK cells, whereas its effects on conventional splenic and pulmonary NK cells were minimal. These findings, consistent between human clinical data and murine experiments, suggest that IO promotes a microenvironment conducive to liver metastasis by compromising hepatic immunity.

conclusionsIO exerts a detrimental effect on hepatic immunity by impairing NK cell-mediated antitumor responses, thereby facilitating liver metastasis in CRC.

Indexed as

Colorectal NeoplasmsIntestinal ObstructionKiller Cells, NaturalLiverLiver NeoplasmsAgedAnimalsDisease Models, AnimalFemaleHumansMaleMiceMice, Inbred C57BLMiddle AgedNeoplasm Recurrence, LocalPrognosisColorectal cancerIntestinal obstructionLiver metastasisLiver natural killer cellsTumor necrosis factor-related apoptosis-inducing ligand

Identifiers

PMID41652207
PMCPMC13048930

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.