ArticleBrain imaging and behavior2026
Stress-related white matter microstructure alterations and chronic pain.
Article in Brain imaging and behavior, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Posttraumatic stress symptoms (PTSS) are commonly experienced in people with chronic pain. Reduced white matter microstructural integrity in the uncinate fasciculus and the cingulum has separately been reported in chronic pain and posttraumatic stress disorder (PTSD) studies. However, the relationship between chronic pain, PTSS and white matter integrity remains unclear. This study aims to disentangle the relationship between PTSS severity and white matter microstructural integrity common across different chronic pain conditions. Thirty-six subjects with chronic pain and 20 without chronic pain (controls) underwent diffusion weighted imaging and completed the civilian version of the PTSD CheckList (PCL-C). Average fractional anisotropy (FA) values were extracted from the uncinate fasciculus, and the cingulate and hippocampal portions of the cingulum. A series of multiple linear regressions determined the main effects of group, PTSS severity (PCL-C total score) and their interactions on each region separately. The group-by-PTSS interaction was significantly associated with uncinate fasciculus FA variations. Moderation analysis indicated that increasing PTSS severity was significantly associated with reduced uncinate fasciculus FA in the control group, but not in the chronic pain group. No other significant association was found for any other ROI FA values. Consistent with previous studies, increasing PTSS levels were associated with reduced FA of the uncinate fasciculus in controls, but not in people with chronic pain. Other mechanisms may be at play in chronic pain, including the interplay with other psychopathological problems or specific pain type effects.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.