ArticleCell genomics2026
Nematode extracellular protein interactome expands connections between signaling pathways.
Article in Cell genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed.
- The teneurin TEN-1 and its ligand LRON-11 support microbiota-induced neuroprotection and mechanosensory function in C. elegans.Current biology : CB · 2026Article
- Evolution of NELL binding by dual-ligand-responsive axon guidance receptor Robo.bioRxiv : the preprint server for biology · 2026Article
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- Structure of the Beat-Side complex reveals their interaction is required for neuromuscular system wiring.Cell reports · 2026Article
- A dating app for extracellular adhesion proteins.Cell genomics · 2026Article
- EFN-4/Ephrin converges with SAX-3/Robo, UNC-6/Netrin, and Heparan Sulfate Proteoglycan signaling to control MAB-5/Hox-dependent posterior Q neuroblast migration inbioRxiv : the preprint server for biology · 2026Article
- RoboA reinforces planarian stem cell fate through FoxA and Anosmin1a.Nature communications · 2026Article
- A trans-synaptic IgLON adhesion molecular complex directly contacts and clusters a nicotinic receptor.Nature communications · 2026Article
- Article
- A gene expression atlas of a juvenile nervous system.bioRxiv : the preprint server for biology · 2025Article
- Structural basis and functional roles for Toll-like receptor binding to Latrophilin in C. elegans development.Nature structural & molecular biology · 2025Article
- Repulsive interactions instruct synaptic partner matching in an olfactory circuit.bioRxiv : the preprint server for biology · 2025Article
- Structural insights into wiring specificity in the neuromuscular system through the Beat-Side complex.bioRxiv : the preprint server for biology · 2025Article
- Article
- Expanding ligand-receptor interaction networks for axon guidance: Structural insights into signal crosstalk and specificity.Current opinion in neurobiology · 2025Review
- Pluripotent Stem Cell Plasticity is Sculpted by a Slit-Independent Robo Pathway in a Regenerative Animal.bioRxiv : the preprint server for biology · 2025Article
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10 authors.
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Abstract
The nematode Caenorhabditis elegans is a favorable model for studying cell-surface protein interactomes, given its well-defined and stereotyped intercellular contacts. Here, we report an extracellular interactome dataset for C. elegans. Most of these interactions were unknown, despite recent datasets for flies and humans, as our collection contains a larger selection of protein families. We uncover interactions for all four major axon guidance pathways, including ectodomain interactions between three of them. We demonstrate that a protein family, previously known for maintaining axon positioning, functions as secreted binders for insulins and that their overexpression in vivo extends lifespan, consistent with inhibition of insulin signaling. We reveal interactions of cystine-knot proteins with putative signaling receptors, which may extend the study of neurotrophins and growth factors to nematodes. Finally, our dataset constitutes a resource for uncovering the logic of neuronal connectivity, intercellular communication and adhesion, and signaling pathways involved in aging and disease.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.