Evidence map›Paper›PMID 41654014›Full record

ArticleMolecular metabolism2026

Semaphorin 7A regulates axon outgrowth in subcutaneous white adipose tissue.

Jake W Willows, Lindsey M Lazor, Gabriela Wandling, William Butke, Fatma Fenesha, Kara N Corps, Sarah B Peters, Kristy L Townsend

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Semaphorins and Their Role in Neuropathic Pain.Life (Basel, Switzerland) · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jake W WillowsDepartment of Neurological Surgery, The Ohio State University College of Medicine and Wexner Medical Center, Columbus, OH, USA.
Lindsey M LazorDepartment of Neurological Surgery, The Ohio State University College of Medicine and Wexner Medical Center, Columbus, OH, USA.
Gabriela WandlingDivision of Biosciences, College of Dentistry, The Ohio State University, Columbus, OH, USA.
William ButkeDepartment of Neurological Surgery, The Ohio State University College of Medicine and Wexner Medical Center, Columbus, OH, USA.
Fatma FeneshaDivision of Biosciences, College of Dentistry, The Ohio State University, Columbus, OH, USA.
Kara N CorpsDepartment of Veterinary Bioscience, The Ohio State University College of Veterinary Medicine, Columbus, OH, USA.
Sarah B PetersDivision of Biosciences, College of Dentistry, The Ohio State University, Columbus, OH, USA.
Kristy L TownsendDepartment of Neurological Surgery, The Ohio State University College of Medicine and Wexner Medical Center, Columbus, OH, USA. Electronic address: kristy.townsend@osumc.edu.

Funding

Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DAVID P OLSON · 2013 to 2026
$24.3M
SEMA7a regulation of tooth mineralization, root elongation, and innervationR03DE033966 · NIDCR · OHIO STATE UNIVERSITY · PI PETERS, SARAH · 2024 to 2025
$315k
NIDCR NIH HHS R03 DE033966NIDDK NIH HHS P30 DK020572
6 · The paper itself

Abstract

purposeAdipose tissue innervation is critical for regulating lipolysis, adipogenesis, and thermogenesis, yet the mechanisms that establish and maintain these neural networks remain poorly understood. Semaphorin 7A (Sema7A) is a well-characterized axon guidance and neuroimmune signaling molecule that is highly expressed in adipose tissue. Sema7A regulates adipocyte metabolic processes, including lipid accumulation and thermogenic gene expression, via Integrin β1 signaling. However, its potential role in shaping adipose tissue innervation and coordinating neural-metabolic communication has not been explored.

methodsIn this study, we investigated a knockout of Sema7A in mice, and its influences on adipose tissue innervation and metabolic regulation during postnatal development and in adulthood, both under baseline conditions and following cold exposure, a potent activator of sympathetic nerve activity and axonal remodeling in scWAT.

resultsDeletion of Sema7A increased adiposity at postnatal day 21, marked by enlarged subcutaneous and brown adipose depots and reduced lipolytic enzyme expression. Tyrosine hydroxylase-expressing (TH

conclusionsTogether, these findings identify Sema7A as a critical mediator of adipose neural development and remodeling, required for establishing and maintaining proper innervation and metabolic function.

Indexed as

Adipose Tissue, WhiteAntigens, CDAxonsSemaphorinsSubcutaneous FatAnimalsGPI-Linked ProteinsLipolysisMaleMiceMice, Inbred C57BLMice, KnockoutThermogenesisAntigens, CDGPI-Linked ProteinsSema7a protein, mouseSemaphorinsAdipose tissueAxon outgrowthInnervationLipolysisSemaphorin 7AThermogenesis

Identifiers

PMID41654014
PMCPMC12925435

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.