Tributyltin induces conjugation of ATG8s to single membranes via the V-ATPase-ATG16L1 axis, leading to transcription factor EB activation in human cell lines.

Shunichi Hatamiya, Masatsugu Miyara, Nanako Takahashi, Ami Oguro, Yaichiro Kotake

Abstract read

In one paragraph

Article in Archives of toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Shunichi HatamiyaGraduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, 734-8553, Japan.

Masatsugu MiyaraGraduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, 734-8553, Japan. miyara128@hiroshima-u.ac.jp.ORCID 0000-0001-6132-8286

Nanako TakahashiGraduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, 734-8553, Japan.

Ami OguroGraduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, 734-8553, Japan.ORCID 0000-0003-3461-1259

Yaichiro KotakeGraduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, 734-8553, Japan. yaichiro@hiroshima-u.ac.jp.ORCID 0000-0003-2645-3078

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tributyltin (TBT) is an environmental contaminant that induces diverse toxic effects in mammals, but the cellular mechanisms underlying adaptation to TBT stress remain poorly understood. Conjugation of ATG8s to single membranes (CASM) is a noncanonical LC3‑lipidation pathway activated by various stressors, distinct from canonical autophagy. We previously showed that TBT reduces lysosomal acidity and inhibits autophagy in SH-SY5Y cells. Furthermore, we observed TBT-induced LC3-II accumulation, which was reduced by bafilomycin A

Indexed as

Autophagy-Related Protein 8 FamilyAutophagy-Related ProteinsBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsTrialkyltin CompoundsVacuolar Proton-Translocating ATPasesAutophagyCell Line, TumorEnvironmental PollutantsHeLa CellsHumansLysosomesMacrolidesMicrotubule-Associated ProteinsATG16L1 protein, humanAutophagy-Related Protein 8 FamilyAutophagy-Related Proteinsbafilomycin A1Basic Helix-Loop-Helix Leucine Zipper Transcription FactorsEnvironmental PollutantsMacrolidesMAP1LC3A protein, humanMicrotubule-Associated ProteinsTFEB protein, humanTrialkyltin CompoundstributyltinVacuolar Proton-Translocating ATPasesCASMLC3LysosomeNoncanonical autophagyTFEBTributyltin

Identifiers

PMID41654644

DOI10.1007/s00204-026-04300-7

PMCPMC13086666

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.