Evidence map›Paper›PMID 41654760›Full record

ArticleBMC neurology2026

A carotid web with accumulation of myofibroblasts: a case report.

Saki Kotani, Ryoji Yasumizu, Yasuhiro Takeuchi, Takumi Yamanaka, Kazuyuki Kuwayama, Keigo Matsumoto

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PubMed Full text at PMC Publisher
In one paragraph

Article in BMC neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Saki KotaniDepartment of Neurosurgery, Community Healthcare Organization, Kobe Central Hospital, 2-1-1, Soyama-Cho, Kita-Ku, Kobe, Hyogo, Japan. saki-k@koto.kpu-m.ac.jp.
Ryoji YasumizuDepartment of Pathology, Japan Community Healthcare Organization Kobe Central Hospital, Hyogo, Japan.
Yasuhiro TakeuchiDepartment of Neurosurgery, Community Healthcare Organization, Kobe Central Hospital, 2-1-1, Soyama-Cho, Kita-Ku, Kobe, Hyogo, Japan.
Takumi YamanakaDepartment of Neurosurgery, Community Healthcare Organization, Kobe Central Hospital, 2-1-1, Soyama-Cho, Kita-Ku, Kobe, Hyogo, Japan.
Kazuyuki KuwayamaDepartment of Neurosurgery, Community Healthcare Organization, Kobe Central Hospital, 2-1-1, Soyama-Cho, Kita-Ku, Kobe, Hyogo, Japan.
Keigo MatsumotoDepartment of Neurosurgery, Community Healthcare Organization, Kobe Central Hospital, 2-1-1, Soyama-Cho, Kita-Ku, Kobe, Hyogo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCarotid webs are increasingly recognized as potential sources of ischemic stroke among young patients without conventional cardiovascular risk factors. However, its pathophysiological mechanism remains unclear. We report a case in which a carotid web was resected via carotid endarterectomy (CEA), allowing for histological analysis. PATIENT PRESENTATION: In a 49-year-old male, stenosis of the left internal carotid artery occurred via magnetic resonance imaging for medical examination. Carotid ultrasonography revealed turbulent blood flow around a flap-like lesion, which was consistent with a carotid web. Because this hemodynamic disturbance may increase the risk of ischemic stroke, CEA was performed. Histopathological examination revealed intimal hyperplasia with the accumulation of myofibroblast-like cells.

conclusionOur pathological findings revealed intimal thickening and fibrosis and proliferation of SMA-positive, desmin-negative myofibroblast-like cells, suggesting that the dysregulation of myofibroblasts may underlie the pathogenesis of carotid webs.

Indexed as

Carotid StenosisCarotid WebsMyofibroblastsEndarterectomy, CarotidHumansMaleMiddle AgedCarotid endarterectomyCarotid webMyofibroblastNeural crest cell

Identifiers

PMID41654760
PMCPMC12883081

What Socratic holds

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