Evidence map›Paper›PMID 41654813›Full record

ArticleCell communication and signaling : CCS2026

Protein disulfide isomerase A6 (PDIA6) is essential for acrosome biogenesis and male fertility in mice.

Xiaofeng Yan, Yaqiong Zhang, Aizhen Yang, Yufeng Hou, Raymond B Birge, Jinxing Lv, Yi Wu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell communication and signaling : CCS, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xiaofeng YanNational Clinical Research Center for Hematologic Diseases, Cyrus Tang Medical Institute, Collaborative Innovation Center of Hematology, State Key Laboratory of Radiation Medicine and Prevention, The Fourth Affiliated Hospital of Soochow University, Soochow University, Suzhou, 215123, China. xiaofeng_yan@yeah.net.
Yaqiong ZhangNational Clinical Research Center for Hematologic Diseases, Cyrus Tang Medical Institute, Collaborative Innovation Center of Hematology, State Key Laboratory of Radiation Medicine and Prevention, The Fourth Affiliated Hospital of Soochow University, Soochow University, Suzhou, 215123, China.
Aizhen YangNational Clinical Research Center for Hematologic Diseases, Cyrus Tang Medical Institute, Collaborative Innovation Center of Hematology, State Key Laboratory of Radiation Medicine and Prevention, The Fourth Affiliated Hospital of Soochow University, Soochow University, Suzhou, 215123, China.
Yufeng HouNational Clinical Research Center for Hematologic Diseases, Cyrus Tang Medical Institute, Collaborative Innovation Center of Hematology, State Key Laboratory of Radiation Medicine and Prevention, The Fourth Affiliated Hospital of Soochow University, Soochow University, Suzhou, 215123, China.
Raymond B BirgeDepartment of Microbiology, Biochemistry and Molecular Genetics, Center for Cell Signaling, Rutgers New Jersey Medical School, 205 South Orange Ave, Newark, NJ, 07103, USA.
Jinxing LvNational Clinical Research Center for Hematologic Diseases, Cyrus Tang Medical Institute, Collaborative Innovation Center of Hematology, State Key Laboratory of Radiation Medicine and Prevention, The Fourth Affiliated Hospital of Soochow University, Soochow University, Suzhou, 215123, China. szdalv@163.com.
Yi WuNational Clinical Research Center for Hematologic Diseases, Cyrus Tang Medical Institute, Collaborative Innovation Center of Hematology, State Key Laboratory of Radiation Medicine and Prevention, The Fourth Affiliated Hospital of Soochow University, Soochow University, Suzhou, 215123, China. wuy@suda.edu.cn.

Funding

Key Project of Science and Education Strengthening Healthcare in Suzhou ZDXM2024009National Natural Science Foundation of China 82170129, 82470132, 81970128, 31970890National Natural Science Foundation of China 82270136Suzhou Industrial Park Healthcare Innovation Research Project CXYJ2024B06Suzhou Science and Technology Project-Collaborative Innovation Research on Medical-Engineering Integration SZM2024006the collaboration fund from State Key Laboratory of Radiation Medicine and Protection GZN1201802the Introduce Project of Clinical Medicine Experts of Suzhou Industrial Park SZYQTD202104the Priority Academic Program Development of Jiangsu Higher Education Institutions PAPDTranslational Research Grant of NCRCH 2020ZKPA02, 2020WSA04
6 · The paper itself

Abstract

backgroundThe family of protein disulfide isomerases (PDIs) are thiol oxidoreductases located predominantly in the endoplasmic reticulum that catalyze thiol-disulfide exchange for normal protein folding. Recent studies have shown that this family enzymes such as PDI contribute to the meiosis of spermatocytes and male fertility. However, the role of PDIA6 in the PDI family in spermatogenesis has not been characterized using genetically modified animal models.

methodsA premeiotic PDIA6 conditional knockout (Stra8-Cre/Pdia6

resultsAbnormal round-headed shape resembling partial globozoospermia was observed in Stra8-Cre/Pdia6

conclusionsPDIA6 is essential for redox regulation of protein synthesis and spermatogenesis causing male fertility in mice.

Indexed as

AcrosomeFertilityProtein Disulfide-IsomerasesAnimalsMaleMiceMice, KnockoutSpermatogenesisSperm ProteinsPdia6 protein, mouseProtein Disulfide-IsomerasesSperm ProteinsAcrosome biogenesisMale infertilityPDIA6RedoxSperm morphogenesis

Identifiers

PMID41654813
PMCPMC13041212

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.