ArticleCardiovascular diabetology2026
Cumulative exposure to the estimated glucose disposal rate and incident stroke in individuals with cardiovascular-kidney-metabolic syndrome stages 0-4: 6-year longitudinal evidence from CHARLS.
Article in Cardiovascular diabetology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Longitudinal associations of cumulative and repeated-measure patterns of insulin resistance surrogate indices with biological age acceleration and incident cardiovascular disease across cardiovascular-kidney-metabolic syndrome stages 0-3: evidence from CHARLS 2011-2020.Cardiovascular diabetology · 2026Article
- Changes in the estimated glucose disposal rate and cardiometabolic multimorbidity in middle-aged and older adults.Cardiovascular diabetology · 2026Article
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6 authors.
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Abstract
backgroundThe estimated glucose disposal rate (eGDR), an established measure of peripheral insulin sensitivity, contributes to stratifying the risk of cardio-cerebrovascular events. Nevertheless, the association between long-term eGDR exposure and stroke incidence throughout all stages (0-4) of cardiovascular-kidney-metabolic (CKM) syndrome remains unknown.
methodsA cohort of 5248 individuals was drawn from the China Health and Retirement Longitudinal Study (CHARLS). For each participant, eGDR values for the years 2012 and 2015 were calculated using the equation: 21.158 - [0.090 × WC (cm)] - [3.407 × HTN (presence = 1)] - [0.551 × HbA1c (%)]. Cumulative eGDR was calculated as (eGDR
resultsDuring the 2015-2018 follow-up period, a total of 336 incident stroke cases were documented. Four distinct eGDR change patterns were identified. In fully adjusted models, compared with the participants in the persistent low pattern (Class 2), those in the moderate-high stable (OR 0.43, 95% CI: 0.31-0.58), stable high (OR 0.29, 0.19-0.43), and rapid decrease (OR 0.66, 0.47-0.91) patterns exhibited significantly lower stroke risk. Furthermore, each 1-unit increase in cumulative eGDR was associated with a 5% reduction in stroke odds (OR 0.95, 0.93-0.96). Restricted cubic spline analysis confirmed a linear inverse relationship between cumulative eGDR and stroke risk (P < 0.001; P for nonlinearity = 0.259).
conclusionCumulative eGDR is inversely associated with stroke risk across all CKM syndrome stages (0-4). This observation suggests that prolonged eGDR surveillance may be associated with improved risk stratification in this population.
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