Evidence map›Paper›PMID 41655822›Full record

ReviewPharmacological research2026

Pathophysiological significance of the TRPM2 ion channel as a potential target in cancer, neurological disorders, and ischemia/reperfusion injury.

Sara Sultana, Yang Xie, Mir Shahriar Kamal, Wei Li

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Pharmacological research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sara SultanaDepartment of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN 38163, United States.
Yang XieDepartment of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN 38163, United States.
Mir Shahriar KamalDepartment of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN 38163, United States.
Wei LiDepartment of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN 38163, United States. Electronic address: wli@uthsc.edu.

Funding

Targeting the colchicine site in tubulin for advanced melanomaR01CA148706 · NCI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI LI, WEI, MILLER, DUANE D · 2011 to 2025
$5.3M
Targeting brain and bone metastases in metastatic breast cancer for improved patient survivalR01CA276152 · NCI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI WEI LI, Tiffany Nicole Seagroves · 2023 to 2026
$2.4M
NCI NIH HHS R01 CA148706NCI NIH HHS R01 CA276152
6 · The paper itself

Abstract

The transient receptor potential melastatin 2 (TRPM2) ion channel is a redox-sensitive, non-specific cation channel that plays a vital role in the regulation of Ca

Indexed as

NeoplasmsNervous System DiseasesReperfusion InjuryTRPM Cation ChannelsAnimalsHumansOxidative StressTRPM2 protein, humanTRPM Cation ChannelsCa(2+) influxCancerIschemia/reperfusion (I/R) injuryNeurological disordersOxidative stressTRPM2 inhibitors

Identifiers

PMID41655822
PMCPMC13001073

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.