Evidence map›Paper›PMID 41656301›Full record

ArticleAnnals of African medicine2026

A Comparative Analysis of the Efficacy of CD117 and Special Stains as Indicators of Mechanical Asphyxial Deaths.

Raghvendra Singh Shekhawat, Rahul Panwar, Meenakshi Rao, Vikas Premlal Meshram, Meena Suresh Kumar, Sridevi Gnanasekaran, Mohini Rathore, Tanuj Kanchan

Abstract readComparative Study
PubMed Full text at PMC Publisher
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Article in Annals of African medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

8 authors.

Raghvendra Singh ShekhawatDepartment of Forensic Medicine and Toxicology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.
Rahul PanwarDepartment of Forensic Medicine and Toxicology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.
Meenakshi RaoDepartment of Pathology and Lab Medicine, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.
Vikas Premlal MeshramDepartment of Forensic Medicine and Toxicology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.
Meena Suresh KumarDepartment of Forensic Medicine and Toxicology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.
Sridevi GnanasekaranDepartment of Community Medicine and Family Medicine, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.
Mohini RathoreDepartment of Biochemistry, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.
Tanuj KanchanDepartment of Forensic Medicine and Toxicology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDetermining the cause of death in suspected asphyxia is often difficult when external findings are absent. Mast cells (MCs) may provide objective histological evidence of hypoxia.

objectiveTo compare the efficacy of immunohistochemistry (IHC) using CD117 with Toluidine Blue (TB) and Giemsa (GM) stains in detecting mast cells in asphyxial and non-asphyxial lung tissues. MATERIALS AND

methodsLung samples from 164 medicolegal autopsies at AIIMS Jodhpur were studied, 57 asphyxial and 107 non-asphyxial deaths. Peribronchial and perialveolar regions were examined using TB, GM, and IHC (CD117). Mean mast cell counts were compared using Mann-Whitney U and Kruskal-Wallis tests.

resultsMast cell counts were significantly higher in asphyxial cases. Peribronchial counts: IHC 2.27 ± 1.02, TB 2.29 ± 1.19, GM 0.84 ± 0.59. Perialveolar counts: IHC 0.74 ± 0.12, TB 0.10 ± 0.19, GM 0.01 ± 0.51. IHC was more sensitive than GM (P < 0.001), while TB showed comparable efficacy to IHC.

conclusionCD117-based IHC is the most sensitive method for identifying mast cells in asphyxial lungs, though TB remains a valuable low-cost option. Mast cell analysis can serve as an adjunct marker in diagnosing mechanical asphyxia.

Indexed as

AsphyxiaImmunohistochemistryLungMast CellsProto-Oncogene Proteins c-kitAdolescentAdultAutopsyCause of DeathCell CountColoring AgentsFemaleHumansMaleMiddle AgedSensitivity and SpecificityColoring AgentsProto-Oncogene Proteins c-kitTolonium ChlorideAsphyxiaAsphyxieforensic pathologyhistopathologiehistopathologyimmunohistochemistryimmunohistochimielungsmast cellsmastocytespathologie médico-légalepoumons

Identifiers

PMID41656301
PMCPMC13645296

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.