Evidence map›Paper›PMID 41656767›Full record

ReviewChannels (Austin, Tex.)2026

Mechanistic insights into Orai dynamics during pore opening.

Hadil Najjar, Veronika Aichner, Magdalena Prantl, Nora Müller, Heinrich Krobath, Isabella Derler

Abstract readReview
In one paragraph

Review in Channels (Austin, Tex.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Evolutionarily conserved hydrophobicity and sterics in TM3/TM4 balance Orai1 pore opening.Protein science : a publication of the Protein Society · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hadil NajjarInstitute of Biophysics, JKU Life Science Center, Johannes Kepler University Linz, Linz, Austria.
Veronika AichnerInstitute of Biophysics, JKU Life Science Center, Johannes Kepler University Linz, Linz, Austria.
Magdalena PrantlInstitute of Biophysics, JKU Life Science Center, Johannes Kepler University Linz, Linz, Austria.
Nora MüllerInstitute of Biophysics, JKU Life Science Center, Johannes Kepler University Linz, Linz, Austria.
Heinrich KrobathInstitute of Theoretical Physics, Johannes Kepler University Linz, Linz, Austria.
Isabella DerlerInstitute of Biophysics, JKU Life Science Center, Johannes Kepler University Linz, Linz, Austria.ORCID 0000-0002-4768-146X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Orai channels form highly Ca

Indexed as

Calcium Release Activated Calcium ChannelsORAI1 ProteinAnimalsCalciumCell MembraneEndoplasmic ReticulumHumansIon Channel GatingCalciumCalcium Release Activated Calcium ChannelsORAI1 Proteincalcium (Ca2+), CRAC channelsinter- and intra-transmembrane domain contact sites, hydration, genetic code expansion, crosslinkingIon channels, SOCEOrai1protein dynamicsSTIM1

Identifiers

PMID41656767
PMCPMC12893689

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.