Evidence map›Paper›PMID 41657199›Full record

ArticleStroke2026

Cortical Oscillations as an Endophenotype Mediating ApoE-ε2 Effects on Poststroke Functional Status.

Célia Delcamp, Anne Schwarz, Kathie Jean Ngo, Darice Y Wong, Brent L Fogel, Ramesh Srinivasan, Steven C Cramer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stroke, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Célia DelcampDepartment of Neurology (C.D., A.S., K.J.N., D.Y.W., B.L.F., S.C.C.), David Geffen School of Medicine, University of California, Los Angeles.ORCID 0000-0002-2303-0769
Anne SchwarzDepartment of Neurology (C.D., A.S., K.J.N., D.Y.W., B.L.F., S.C.C.), David Geffen School of Medicine, University of California, Los Angeles.ORCID 0000-0001-8943-5673
Kathie Jean NgoDepartment of Neurology (C.D., A.S., K.J.N., D.Y.W., B.L.F., S.C.C.), David Geffen School of Medicine, University of California, Los Angeles.ORCID 0000-0002-2092-410X
Darice Y WongDepartment of Neurology (C.D., A.S., K.J.N., D.Y.W., B.L.F., S.C.C.), David Geffen School of Medicine, University of California, Los Angeles.ORCID 0009-0000-6257-1667
Brent L FogelDepartment of Neurology (C.D., A.S., K.J.N., D.Y.W., B.L.F., S.C.C.), David Geffen School of Medicine, University of California, Los Angeles.ORCID 0000-0001-9831-1576
Ramesh SrinivasanDepartment of Cognitive Sciences (R.S.), University of California, Irvine.ORCID 0000-0002-2090-8257
Steven C CramerDepartment of Neurology (C.D., A.S., K.J.N., D.Y.W., B.L.F., S.C.C.), David Geffen School of Medicine, University of California, Los Angeles.ORCID 0000-0002-6214-6211

Funding

Validation of Early Prognostic Data for Recovery Outcomes after Stroke for Future, Higher Yield Trials (VERIFY)U01NS120910 · NINDS · YALE UNIVERSITY · PI Steven C. Cramer, Pooja Khatri · 2021 to 2026
$13.5M
Motor Recovery through Plasticity-Inducing Cortical StimulationUH3NS121565 · NINDS · UNIVERSITY OF WASHINGTON · PI Steven C. Cramer, Jeffrey G Ojemann · 2022 to 2026
$4.5M
Telerehabilitation In The Home After Stroke: A Randomized, Controlled, Assessor-Blind Clinical Trial (The TR-2 Trial)UH3NS133283 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CRAMER, STEVEN C., EDWARDS, DYLAN JAMES · 2025 to 2025
$4.5M
NINDS NIH HHS U01 NS120910NINDS NIH HHS UH3 NS121565NINDS NIH HHS UH3 NS133283
6 · The paper itself

Abstract

backgroundAbundant data link ApoE (apolipoprotein E)-ε2 with favorable outcomes in several neurological settings and in healthy subjects, but studies in relation to stroke outcomes are few. ApoE-ε2 activities are associated with poststroke cortical oscillations, which themselves are correlated with poststroke outcomes. The aim of this cohort study was to determine whether cortical oscillations could represent an endophenotype mediating the effects of ApoE-ε2 on poststroke function.

methodsIn 33 patients with recent stroke, resting EEG activity (3 minutes), APOE genotype, and functional outcome (GG scores) were measured. ANCOVAs and partial Pearson correlations were performed to validate the prerequisites for mediation analyses, in which EEG cortical power was tested as a mediator of the relationship between APOE-ε2 and functional outcome.

resultsApoE-ε2 carriers showed higher ipsilesional beta power and lower ipsilesional theta power, both of which were linked to better functional outcomes. The principal mediation analysis revealed an indirect effect of ApoE-ε2 on functional outcome via ipsilesional M1 beta power (ACME, 14.79 [0.9-34.6],

conclusionsThe mediation analysis results suggests that ApoE-ε2 supports a pro-repair environment, which may translate into more favorable cortical dynamics after stroke. Cortical oscillatory activity may be considered as an endophenotype that mediates the effects of ApoE-ε2 on functional outcome and could potentially be leveraged as a biomarker to develop personalized interventions targeting stroke recovery.

Indexed as

Apolipoprotein E2Cerebral CortexEndophenotypesRecovery of FunctionStrokeAgedElectroencephalographyFemaleGenotypeHumansMaleMiddle AgedApolipoprotein E2endophenotypefunctional statusinflammationoxidative stressremyelination

Identifiers

PMID41657199
PMCPMC12888798

What Socratic holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.