ArticleFrontiers in medicine2025
Mitochondrial respiratory dysfunctions of alveolar macrophages in interstitial lung disease: an exploratory study of bioenergetic and clinical links.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Intracellular metabolism is essential for macrophage function. However, the association between the metabolic profile of alveolar macrophages (AMs), which are responsible for pulmonary innate immune responses, and the progression of pulmonary fibrosis in humans remains unclear. Methods: This exploratory study investigated whether mitochondrial bioenergetics in bronchoalveolar lavage (BAL)-derived AMs can distinguish interstitial lung disease (ILD) from non-ILD conditions. A total of 12 patients undergoing diagnostic BAL were analyzed (ILD, Results: The AMs in ILD showed reduced ATP-linked respiration (3.55 vs. 10.67 pmol/min/10 Conclusion: This bioenergetic profile may offer preliminary insights into mitochondrial bioenergetic alterations in AMs from ILDs and their potential relevance to disease characterization. Larger longitudinal studies are warranted to validate these findings and their clinical utility.
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