Evidence map›Paper›PMID 41657939›Full record

ArticleHemaSphere2026

Additive effect of multiple genetic variants in

Antonella Nostroso, Roberta Marra, Barbara Eleni Rosato, Anthony Iscaro, Federica Maria Esposito, Vanessa D'Onofrio, Manuela Dionisi, Michela Ribersani, Francesca Giordano, Anna Bulla and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in HemaSphere, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Antonella NostrosoDepartment of Molecular Medicine and Medical Biotechnology University of Naples Federico II Naples Italy.
Roberta MarraDepartment of Molecular Medicine and Medical Biotechnology University of Naples Federico II Naples Italy.
Barbara Eleni RosatoDepartment of Molecular Medicine and Medical Biotechnology University of Naples Federico II Naples Italy.
Anthony IscaroDepartment of Molecular Medicine and Medical Biotechnology University of Naples Federico II Naples Italy.
Federica Maria EspositoDepartment of Molecular Medicine and Medical Biotechnology University of Naples Federico II Naples Italy.
Vanessa D'OnofrioDepartment of Molecular Medicine and Medical Biotechnology University of Naples Federico II Naples Italy.
Manuela DionisiCEINGE Biotecnologie Avanzate Franco Salvatore Naples Italy.
Michela RibersaniDepartment of Translational and Precision Medicine University of Rome Sapienza Rome Italy.
Francesca GiordanoDepartment of Translational and Precision Medicine University of Rome Sapienza Rome Italy.
Anna BullaAzienda Ospedaliera Universitaria Policlinico "G. Rodolico - San Marco" Catania Italy.
Giovanni Carlo Del VecchioU.O.C. Pediatria Generale e Specialistica "Bruno Trambusti" Bari Italy.
Saverio ScianguettaPediatric Hematology and Oncology Unit of the AOU University of Campania "L. Vanvitelli" Naples Italy.
Giorgia MandrileSSD Microcitemie, AOU San Luigi Gonzaga Orbassano Turin Italy.
Teresa CeglieSSD Microcitemie, AOU San Luigi Gonzaga Orbassano Turin Italy.
Olga ScudieroDepartment of Molecular Medicine and Medical Biotechnology University of Naples Federico II Naples Italy.
Giovanni Battista FerreroSSD Microcitemie, AOU San Luigi Gonzaga Orbassano Turin Italy.ORCID https://orcid.org/0000-0002-3793-5788
Silverio PerrottaPediatric Hematology and Oncology Unit of the AOU University of Campania "L. Vanvitelli" Naples Italy.
Achille IolasconDepartment of Molecular Medicine and Medical Biotechnology University of Naples Federico II Naples Italy.
Immacolata AndolfoDepartment of Molecular Medicine and Medical Biotechnology University of Naples Federico II Naples Italy.ORCID https://orcid.org/0000-0003-0493-812X
Roberta RussoDepartment of Molecular Medicine and Medical Biotechnology University of Naples Federico II Naples Italy.ORCID https://orcid.org/0000-0002-3624-7721

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hereditary anemias encompass a genetically heterogeneous spectrum of disorders, often involving multi-locus inheritance, which can complicate clinical management and worsen disease severity. This study investigates the impact of the co-inheritance of

Identifiers

PMID41657939
PMCPMC12880738

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.