Evidence map›Paper›PMID 41657986›Full record

ArticleFrontiers in microbiology2025

JR20, a novel natural product-derived compound, exhibits potent anti-biofilm activity against methicillin-resistant

Meirong Zhao, Chaowei Zhang, Yogini Jaiswal, Xinrong Xie, Dongyu Huang, Zhendan He, Leonard Williams, Yifu Guan, Hedong Bian, Xun Song

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Meirong Zhao *School of Chemistry and Chemical Engineering, Guangxi Minzu University, Nanning, China.
Chaowei Zhang *College of Pharmacy, Shenzhen Technology University, Shenzhen, China.
Yogini Jaiswal *Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University, The North Carolina Research Campus, Kannapolis, NC, United States.
Xinrong XieSchool of Chemistry and Chemical Engineering, Guangxi Minzu University, Nanning, China.
Dongyu HuangSchool of Pharmacy, Shenzhen University Medical School, Shenzhen University, Shenzhen, China.
Zhendan HeCollege of Pharmacy, Shenzhen Technology University, Shenzhen, China.
Leonard WilliamsCenter for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University, The North Carolina Research Campus, Kannapolis, NC, United States.
Yifu GuanSchool of Chemistry and Chemical Engineering, Guangxi Minzu University, Nanning, China.
Hedong BianSchool of Chemistry and Chemical Engineering, Guangxi Minzu University, Nanning, China.
Xun SongCollege of Pharmacy, Shenzhen Technology University, Shenzhen, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: JR20, a novel sesamin-derived arylnaphthalene lignan, has demonstrated potent antifungal activity. This study further investigates its antibacterial potential against MRSA (methicillin-resistant Methods: The highlights of this research include the use of SYTO9 and PI fluorescence double staining, along with three-dimensional confocal microscopy to reveal the thickness and viability of biofilms under JR0's influence. Additionally, scanning and transmission electron microscopy were employed to observe the morphological changes of MRSA under JR0's impact. By combining the observed reduction in ATP content within MRSA, a preliminary mechanism was hypothesized. Results: JR20 exhibited potent anti-MRSA activity (IC Conclusion: This study confirms JR0's potent anti-MRSA activity, clarifies its effects on biofilms and MRSA morphology, and proposes a preliminary mechanism by reduced ATP. JR20 demonstrates significant potential for combating drug-resistant bacteria and advancing antibiofilm drug discovery.

Indexed as

antibiotic-resistant bacteriaarylnaphthalene lignanbiofilm disruptionconfocal microscopyMRSA

Identifiers

PMID41657986
PMCPMC12872765

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.