Evidence map›Paper›PMID 41658422›Full record

SynthesisInternational journal of public health2026

Access to Essential Medicines in Low- and Middle-Income Countries: A Systematic Review of Barriers and Facilitators.

Israel Herrera-Ramirez, Emanuel Orozco-Nuñez, Germán Guerra, Anahi Dreser-Mansilla, Raul Enrique Molina-Salazar

Abstract readSystematic ReviewReview
In one paragraph

Synthesis in International journal of public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Israel Herrera-RamirezCenter for Health Systems Research, National Institute of Public Health, Cuernavaca, Mexico.
Emanuel Orozco-NuñezCenter for Health Systems Research, National Institute of Public Health, Cuernavaca, Mexico.
Germán GuerraCenter for Health Systems Research, National Institute of Public Health, Cuernavaca, Mexico.
Anahi Dreser-MansillaCenter for Health Systems Research, National Institute of Public Health, Cuernavaca, Mexico.
Raul Enrique Molina-SalazarDepartment of Economics, Universidad Autónoma Metropolitana Iztapalapa, Mexico City, Mexico.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: To conduct a systematic review to analyze the barriers and facilitators related to accessing essential medicines in low- and middle-income countries (LMICs). Methods: We searched PubMed, SciELO, LILACS, and Web of Science for studies published between 2002 and 2025. Studies were included if they were peer-reviewed, written in English or Spanish, and reported data on barriers or facilitators across three dimensions: availability, affordability, and adequate use. Results: From 1010 identified records, 36 studies were included. Most were quantitative (n = 26), followed by qualitative (n = 8) and mixed-methods (n = 2) designs. Barriers (n = 34 studies) were reported more frequently than facilitators (n = 25), particularly for availability and affordability. Key barriers included public sector stock-outs and high prices in the private sector. A key facilitator was the presence of a national essential medicines list. Conclusion: Our analysis compiles evidence on barriers and facilitators affecting access to essential medicines in LMICs. Policies favoring generic drug procurement and public-private sector disparities highlight the complexity of ensuring equitable access.

Indexed as

Developing CountriesDrugs, EssentialHealth Services AccessibilityHumansPrivate SectorPublic SectorDrugs, Essentialaccess to medicinesaffordabilityappropriate useavailabilityessential medicineshealth governancelow- and middle-income countries

Identifiers

PMID41658422
PMCPMC12877563

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.