ArticleReports of biochemistry & molecular biology2025
Gal-3 Expression in Oral and Lip SCC: Histopathological Correlation via Immunohistochemistry.
Article in Reports of biochemistry & molecular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Oral and lip squamous cell carcinomas (OSCC) are malignancies among head and neck cancers. OSCC is characterized by aggressive behavior and poorer prognosis compared to other squamous cell carcinomas. Galectin-3 (Gal-3) is a multifunctional protein involved in processes such as cell proliferation, apoptosis, and metastasis. This study aims to evaluate and compare Gal-3 expression among groups to investigate its role in the biological behaviors of lip and oral SCCs. Methods: Immunohistochemical analysis of Gal-3 was performed on OSCC and lip SCC samples, with oral and lip marginal tissues obtained as the control group. The clinicopathological parameters, including the invasive front (IF), depth of invasion (DOI), and muscular, neural, and vascular invasions, were assessed. The staining percentage, intensity, and cellular location of Gal-3 were compared between the study groups. A p-value of < 0.05 was considered statistically significant. Results: Gal-3 staining percentages were significantly higher in the SCC groups compared to control groups (P< 0.001 for each). Staining intensity and nuclear staining were higher in OSCC than in lip SCC (P< 0.001, P< 0.010, respectively). Nuclear Gal-3 was notably associated with the presence of muscle invasion in OSCC (P=0.030). High IF status was correlated with Gal-3 expression in lip SCC (P=0.010). Staining intensity was significantly higher in OSCC samples with vascular invasion compared to those without (P= 0.016). Conclusions: The higher Gal-3 expression and nuclear staining in OSCC may explain its aggressive nature. Gal-3 could be a diagnostic and prognostic biomarker due to its increased expression in cancerous tissues compared to normal samples.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.