Evidence map›Paper›PMID 41659402›Full record

ArticlebioRxiv : the preprint server for biology2026

Interferon lambda signaling to maternal dendritic cells protects against congenital Zika virus infection.

Margaret R Dedloff, Thomas R Reinhardt, Tessa-Jonne F Ropp, Joel Rivera-Cardona, Celeste R Robles, Rebecca L Casazza, J Ashley Ezzell, Michelle S Itano, Helen M Lazear

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Margaret R DedloffDepartment of Microbiology & Immunology, University of North Carolina at Chapel Hill.ORCID 0000-0002-0175-116X
Thomas R ReinhardtDepartment of Microbiology & Immunology, University of North Carolina at Chapel Hill.ORCID 0009-0003-4749-8213
Tessa-Jonne F RoppNeuroscience Microscopy Core Facility, Carolina Institute for Developmental Disabilities & Neuroscience Center, University of North Carolina at Chapel Hill.ORCID 0000-0001-9831-0557
Joel Rivera-CardonaDepartment of Microbiology & Immunology, University of North Carolina at Chapel Hill.ORCID 0000-0002-2630-6740
Celeste R RoblesDepartment of Microbiology & Immunology, University of North Carolina at Chapel Hill.ORCID 0000-0002-4854-7676
Rebecca L CasazzaDepartment of Microbiology & Immunology, University of North Carolina at Chapel Hill.ORCID 0000-0002-8271-6947
J Ashley EzzellHistology Research Core Facility, Department of Cell Biology & Physiology, University of North Carolina at Chapel Hill.ORCID 0000-0002-5142-4685
Michelle S ItanoNeuroscience Microscopy Core Facility, Carolina Institute for Developmental Disabilities & Neuroscience Center, University of North Carolina at Chapel Hill.ORCID 0000-0001-6853-1228
Helen M LazearDepartment of Microbiology & Immunology, University of North Carolina at Chapel Hill.ORCID 0000-0002-8649-4579

Funding

Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HONG JIN KIM · 1985 to 2026
$201.5M
Preclinical CoreP50HD103573 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GABRIEL S DICHTER · 2020 to 2026
$9.7M
Molecular Biology of Viral Diseases Predoctoral Training GrantT32AI007419 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Mark T Heise, CARY A MOODY · 1993 to 2026
$4.7M
Antiviral and immunomodulatory effects of interferon lambda in the skinR01AI175708 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Helen Lazear · 2023 to 2026
$2.4M
The role of Interferon lambda signaling in flavivirus transmission and pathogenesis at the maternal-fetal interfaceR01AI139512 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LAZEAR, HELEN · 2019 to 2023
$1.9M
UNC Initiative for Maximizing Student DevelopmentT32GM152779 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FREEMAN, ASHALLA MAGEE, KASH, THOMAS L. · 2024 to 2025
$1.2M
NCI NIH HHS P30 CA016086NIAID NIH HHS R01 AI139512NIAID NIH HHS R01 AI175708NIAID NIH HHS T32 AI007419NICHD NIH HHS P50 HD103573NIGMS NIH HHS T32 GM152779
6 · The paper itself

Abstract

Interferon lambda (IFN-λ, type III IFN) mediates antiviral immunity at anatomic barriers, including the maternal-fetal interface. To investigate the effects of IFN-λ during congenital Zika virus (ZIKV) infection, we infected mice lacking the IFN-αβ receptor (

Identifiers

PMID41659402
PMCPMC12873797

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.