Evidence map›Paper›PMID 41659412›Full record

ArticlebioRxiv : the preprint server for biology2026

Biological Mechanisms of Strength Preservation During Calorie Restriction-Induced Weight Loss Among Young- to Middle-Aged Adults without Obesity.

Nadia Moore, Akshay Bareja, Leanna M Ross, Katherine A Collins-Bennett, Susan B Racette, Leanne M Redman, Corby K Martin, Sai Krupa Das, William E Kraus, Kim M Huffman

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Nadia MooreDuke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA.
Akshay BarejaDuke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA.ORCID 0000-0001-9033-4116
Leanna M RossDuke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA.ORCID 0000-0002-1407-1622
Katherine A Collins-BennettDuke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA.ORCID 0000-0001-9712-8980
Susan B RacetteCollege of Health Solutions, Arizona State University, Phoenix, AZ, USA.ORCID 0000-0002-6932-1887
Leanne M RedmanPennington Biomedical Research Center, Baton Rouge, LA, 70808.ORCID 0000-0002-7267-7374
Corby K MartinPennington Biomedical Research Center, Baton Rouge, LA, 70808.ORCID 0000-0002-8125-4015
Sai Krupa DasJean Mayer USDA Human Nutrition Research Center on Aging at Tufts University.ORCID 0000-0003-0788-0461
William E KrausDuke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA.ORCID 0000-0003-1930-9684
Kim M HuffmanDuke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA.ORCID 0000-0003-4708-4734

Funding

Tracking & Evaluation CoreU54GM104940 · NIGMS · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Peter Todd Katzmarzyk · 2012 to 2026
$69.1M
Research BaseP30DK072476 · NIDDK · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Peter Todd Katzmarzyk · 2005 to 2026
$26.5M
Coordinating Center for CALERIEU01AG022132 · NIA · DUKE UNIVERSITY · PI KRAUS, WILLIAM E · 2002 to 2013
$24.9M
Resource Core 3 - Metabolomics CoreP30AG028716 · NIA · DUKE UNIVERSITY · PI Virginia B Kraus · 2006 to 2026
$24.6M
Metabolic Adaptations to Two Year Caloric RestrictionU01AG020478 · NIA · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI RAVUSSIN, ERIC · 2002 to 2008
$13.4M
Caloric Restriction and Aging in HumansU01AG020487 · NIA · WASHINGTON UNIVERSITY · PI HOLLOSZY, JOHN O. · 2001 to 2009
$8.9M
Dietary Energy Restriction and Metabolic Aging in HumansU01AG020480 · NIA · TUFTS UNIVERSITY BOSTON · PI ROBERTS, SUSAN B · 2002 to 2008
$8.2M
ENHANCING THE CALERIE NETWORK TO ADVANCE AGING BIOLOGYR33AG070455 · NIA · DUKE UNIVERSITY · PI KIM M. HUFFMAN, WILLIAM E KRAUS · 2021 to 2026
$4.0M
Sex Differences in Barriers and Predictors of Physical Activity Participation During and Following Cardiac RehabilitationK01HL177266 · NHLBI · DUKE UNIVERSITY · PI Katherine Collins-Bennett · 2025 to 2026
$269k
NHLBI NIH HHS K01 HL177266NIA NIH HHS P30 AG028716NIA NIH HHS R33 AG070455NIA NIH HHS U01 AG020478NIA NIH HHS U01 AG020480NIA NIH HHS U01 AG020487NIA NIH HHS U01 AG022132NIDDK NIH HHS P30 DK072476NIGMS NIH HHS U54 GM104940
6 · The paper itself

Abstract

Purpose: Weight loss is often pursued to improve cardiometabolic health and quality of life. However, rapid weight loss can lead to reductions in lean soft tissue mass and strength to compromise body composition and functional ability. Thus, identifying molecular predictors of muscular strength preservation during weight loss is critical to mitigating these effects. Methods: We conducted a secondary analysis of the CALERIE Results: We identified 96 out of 198 individuals (48.5%) who maintained or improved strength relative to body mass during weight loss ( Conclusions: These findings highlight molecular pathways supporting strength retention during CR-induced weight loss. Heat-shock protein,

Indexed as

caloric restrictiongene expressionlean massskeletal musclestrength retentiontranscriptomicsWeight management

Identifiers

PMID41659412
PMCPMC12873852

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.