Evidence map›Paper›PMID 41659449›Full record

ArticlebioRxiv : the preprint server for biology2026

BESTish: A Diffusion-Approximation Framework for Inferring Selection and Mutation in Clonal Hematopoiesis.

Ren-Yi Wang, Khanh N Dinh, Keito Taketomi, Guodong Pang, Katherine Y King, Marek Kimmel

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ren-Yi WangDepartment of Statistics, Rice University, Houston, TX, USA.
Khanh N DinhIrving Institute for Cancer Dynamics and Department of Statistics, Columbia University, New York, NY, USA.ORCID 0000-0002-0010-4251
Keito TaketomiIrving Institute for Cancer Dynamics and Department of Statistics, Columbia University, New York, NY, USA.
Guodong PangDepartment of Computational Applied Mathematics and Operations Research, Rice University, Houston, TX, USA.
Katherine Y KingDivision of Infectious Diseases, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0002-5093-6005
Marek KimmelDepartment of Statistics, Rice University, Houston, TX, USA.

Funding

Project 3: Contribution of inflammation and DNA damaging factors to clonal expansion and malignant transformation in a community cohort of older adultsP01CA265748 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Daisuke Nakada · 2022 to 2026
$13.6M
Impact of Infection and Inflammation on Primitive HematopoiesisR35HL155672 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI Katherine Yudeh King · 2021 to 2026
$5.1M
NCI NIH HHS P01 CA265748NHLBI NIH HHS R35 HL155672
6 · The paper itself

Abstract

Clonal hematopoiesis (CH) arises when hematopoietic stem cells (HSCs) gain a fitness advantage from somatic mutations and expand, resulting in an increase in variant allele frequency (VAF) over time. To analyze CH trajectories, we develop a state-dependent stochastic model of wild-type and mutant HSCs, in which an environmental parameter

Identifiers

PMID41659449
PMCPMC12879653

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.