Evidence map›Paper›PMID 41659514›Full record

ArticlebioRxiv : the preprint server for biology2026

Notch signaling in the embryonic ectoderm promotes periderm cell fate and represses mineralization of vibrissa hair follicles.

Dianzheng Zhao, Yunus Ozekin, Erin Binne, Irene Choi, Aftab Taiyab, Trevor Williams, Hong Li

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Dianzheng ZhaoDepartment of Craniofacial Biology, University of Colorado Anschutz Medical Campus, Aurora CO 80045, USA.
Yunus OzekinDepartment of Craniofacial Biology, University of Colorado Anschutz Medical Campus, Aurora CO 80045, USA.
Erin BinneDepartment of Craniofacial Biology, University of Colorado Anschutz Medical Campus, Aurora CO 80045, USA.
Irene ChoiDepartment of Craniofacial Biology, University of Colorado Anschutz Medical Campus, Aurora CO 80045, USA.
Aftab TaiyabDepartment of Craniofacial Biology, University of Colorado Anschutz Medical Campus, Aurora CO 80045, USA.
Trevor WilliamsDepartment of Craniofacial Biology, University of Colorado Anschutz Medical Campus, Aurora CO 80045, USA.
Hong LiDepartment of Craniofacial Biology, University of Colorado Anschutz Medical Campus, Aurora CO 80045, USA.ORCID 0000-0002-5132-7252

Funding

Role of Ectodermal Signals in Facial Prominence Outgrowth and DevelopmentR01DE019843 · NIDCR · UNIVERSITY OF COLORADO DENVER · PI WILLIAMS, TREVOR J · 2009 to 2013
$1.7M
Transcriptional Regulatory Networks of Craniofacial DevelopmentK01DE030923 · NIDCR · UNIVERSITY OF COLORADO DENVER · PI LI, HONG · 2021 to 2025
$709k
Genes and cell populations involved in orofacial cleftingR03DE028635 · NIDCR · UNIVERSITY OF COLORADO DENVER · PI LI, HONG · 2019 to 2020
$311k
NIDCR NIH HHS K01 DE030923NIDCR NIH HHS R01 DE019843NIDCR NIH HHS R03 DE028635
6 · The paper itself

Abstract

The Notch signaling pathway is a critical means to regulate cell fate choice in animals. Appropriate regulation of this pathway is also required for human face formation as both loss and gain of function mutations of Notch signaling can cause syndromes with craniofacial abnormalities. Here we examine the consequences of manipulation of Notch signaling in the early mouse embryonic ectoderm by either removing the transcriptional effector

Indexed as

cleft lip and palateectodermhair mineralizationNotch signalingperidermWnt signaling

Identifiers

PMID41659514
PMCPMC12873787

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.