Evidence mapPaperPMID 41659628Full record

ArticlebioRxiv : the preprint server for biology2026

Metabolic modeling and functional genomics reveal taxa and host gene interactions in colorectal cancer.

Katja Della Libera, Elizabeth M Adamowicz, Amanda Muehlbauer, Sambhawa Priya, Adnan Alazizi, Francesca Luca, Ran Blekhman

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Katja Della LiberaSection of Genetic Medicine, Department of Medicine, University of Chicago, Chicago, Illinois, United States of America.ORCID 0000-0001-7174-7986
Elizabeth M AdamowiczFerring Microbiome Inc. Roseville, Minnesota, United States of America.ORCID 0000-0003-3332-8021
Amanda MuehlbauerFerring Microbiome Inc. Roseville, Minnesota, United States of America.ORCID 0000-0001-7043-8444
Sambhawa PriyaSection of Genetic Medicine, Department of Medicine, University of Chicago, Chicago, Illinois, United States of America.ORCID 0000-0003-2821-5620
Adnan AlaziziCenter for Molecular Medicine and Genetics, Wayne State University, Detroit, Michigan, United States of America.ORCID 0000-0002-7599-8114
Francesca LucaDepartment of Human Genetics, University of Chicago, Chicago, Illinois, United States of America.ORCID 0000-0001-8252-9052
Ran BlekhmanSection of Genetic Medicine, Department of Medicine, University of Chicago, Chicago, Illinois, United States of America.ORCID 0000-0003-3218-613X

Funding

Population Genomics of Host-Microbiome InteractionsR35GM128716 · UNIVERSITY OF CHICAGO · 2025 to 2025
$400k
NIGMS NIH HHS R35 GM128716
6 · The paper itself

Abstract

Colorectal cancer (CRC) is associated with changes in the microbial communities in the tumor microenvironment. Although metabolic reprogramming is an important feature of host cells in CRC, little is known about metabolic changes in the tumor-associated microbiota and how these microbial metabolic alterations can contribute to disease. Here, we investigated metabolic host-microbiome interactions in CRC using complementary computational and experimental approaches. Using patient-specific

Identifiers

PMID41659628
PMCPMC12873937

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.