ArticlebioRxiv : the preprint server for biology2026
Activating Ras-MAPK pathway variants drive hippocampal clonal competition in human epilepsy.
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Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
58 authors.
Sattar KhoshkhooDepartment of Neurology, Mass General Brigham, Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-3348-557X
Mingyun BaeDivision of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, MA, USA.
Yilan WangDivision of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, MA, USA.
Ashton TillettDepartment of Neurology, Mass General Brigham, Harvard Medical School, Boston, MA, USA.
Rosita B RamirezDepartment of Neurology, Mass General Brigham, Harvard Medical School, Boston, MA, USA.
Benjamin FinanderDepartment of Neurology, Mass General Brigham, Harvard Medical School, Boston, MA, USA.
Emily D EganDepartment of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
Linus MarxDana Farber/Boston Children's Hospital Cancer and Blood Disorders Center, Boston, MA, USA; Department of Pediatric Hematology and Oncology, University Clinic Münster, Münster, Germany.
Dipan PatelDepartment of Neurology, Mass General Brigham, Harvard Medical School, Boston, MA, USA.
Zinan ZhouDivision of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, MA, USA.ORCID 0000-0003-2014-3650
Yasmine ChahineDivision of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, MA, USA.
Brian ChhoukDivision of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, MA, USA.
Sofia M ZoullasDepartment of Neurology, Mass General Brigham, Harvard Medical School, Boston, MA, USA.
Abbe LaiDepartment of Neurology, Mass General Brigham, Harvard Medical School, Boston, MA, USA.
Roland CorasDepartment of Neuropathology, University Hospitals Erlangen, Erlangen, Germany.
Franck BielleParis Brain Institute, ICM, INSERM, Sorbonne Université, Paris, France.
Vincent NavarroParis Brain Institute, ICM, INSERM, Sorbonne Université, Paris, France.ORCID 0000-0003-0077-8114
Bertrand MathonParis Brain Institute, ICM, INSERM, Sorbonne Université, Paris, France.ORCID 0000-0002-9182-5846
Taufik A ValianteDivision of Neurosurgery, Department of Surgery, University of Toronto, Toronto, ON, Canada.ORCID 0000-0002-3443-3790
Homeira Moradi ChamehDivision of Clinical and Computational Neuroscience, Krembil Brain Institute, University Health Network (UHN), University of Toronto, Toronto, ON, Canada.
Andrew F GaoDepartment of Laboratory Medicine & Pathobiology, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Timo KringsDivision of Neurointerventional Radiology, Lahey Hospital & Medical Center, Beth Israel Lahey Health, UMass Chan Medical School, Boston, MA, USA; Department of Medical Imaging, University of Toronto, Toronto, ON, Canada; Singleton Department of Medical Imaging, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA.
Samuel GooleyEpilepsy Research Centre, Department of Medicine, University of Melbourne, Melbourne, Australia.
Michael S HildebrandEpilepsy Research Centre, Department of Medicine, University of Melbourne, Melbourne, Australia.
Kristian BullussDepartment of Neurosurgery, Austin Health, Heidelberg, Australia.
Jonathan ClarkAnatomical Pathology, Austin Health, Heidelberg, Australia.
Andrew P MorokoffDepartment of Surgery, Royal Melbourne Hospital, University of Melbourne, Parkville, Australia.
James A KingDepartment of Surgery, Royal Melbourne Hospital, University of Melbourne, Parkville, Australia.
Marian TodaroDepartment of Neuroscience, School of Translational Medicine, Monash University, Melbourne, Australia.
Patrick KwanDepartment of Neuroscience, School of Translational Medicine, Monash University, Melbourne, Australia.
Terence J O'BrienDepartment of Neuroscience, School of Translational Medicine, Monash University, Melbourne, Australia.
Samuel F BerkovicEpilepsy Research Centre, Department of Medicine, University of Melbourne, Melbourne, Australia.ORCID 0000-0003-4580-841X
Ingrid E SchefferEpilepsy Research Centre, Department of Medicine, University of Melbourne, Melbourne, Australia.ORCID 0000-0002-2311-2174
Piero PeruccaEpilepsy Research Centre, Department of Medicine, University of Melbourne, Melbourne, Australia.ORCID 0000-0002-7855-7066
Emily LapinskasDepartment of Neurology, Mass General Brigham, Harvard Medical School, Boston, MA, USA.
John D RolstonDepartment of Neurosurgery, Mass General Brigham, Harvard Medical School, Boston, MA, USA.
G Rees CosgroveDepartment of Neurosurgery, Mass General Brigham, Harvard Medical School, Boston, MA, USA.
Rani A SarkisDepartment of Neurology, Mass General Brigham, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-8291-7864
Alissa M D'GamaEpilepsy Genetics Program and F.M. Kirby Neurobiology Center, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Sanda AlexadrescuDepartment of Pathology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Edward YangDepartment of Radiology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Annapurna PoduriEpilepsy Genetics Program and F.M. Kirby Neurobiology Center, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
R Mark RichardsonDepartment of Neurosurgery, Mass General Brigham, Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-2620-7387
E Zeynep Erson-OmayDepartment of Neurosurgery, Yale University School of Medicine, New Haven, CT, USA.
Nihal DeLanerolleDepartment of Neurosurgery, Yale University School of Medicine, New Haven, CT, USA.
Dennis D SpencerDepartment of Neurosurgery, Yale University School of Medicine, New Haven, CT, USA.
Katherine S-M BrownNeuropathology Division, Department of Pathology, Mass General Brigham, Harvard Medical School, Boston, MA, USA.
Michael B MillerDivision of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, MA, USA.ORCID 0000-0002-6205-3314
Amy E RobertsDivision of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, MA, USA.
Luana N SantosDepartment of Biomedical Research and Translational Medicine, Masonic Medical Research Institute, Utica, NY, USA.
Maria I KontaridisDepartment of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-6121-0533
Christian G BienDepartment of Epileptology, Krankenhaus Mara, Bethel Epilepsy Center, Medical School OWL, Bielefeld University, Bielefeld, Germany.
Stephen C BlacklowBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0002-6904-1981
Kristopher T KahleDivision of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, MA, USA.
Ingmar BlümckeDepartment of Neuropathology, University Hospitals Erlangen, Erlangen, Germany.
August Yue HuangDivision of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, MA, USA.ORCID 0000-0002-0416-2854
Eunjung Alice LeeDivision of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, MA, USA.
Christopher A WalshDivision of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, MA, USA.
Funding
Cell Identity Determination In Human Brain: Somatic Mutation and Cell LineageR01NS032457 · NINDS · BOSTON CHILDREN'S HOSPITAL · PI Alice Eunjung Lee, Christopher A. Walsh · 1995 to 2026
$12.7MGenetic Analysis and Manipulation Core (GAEC)P50HD105351 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI SCOTT Loren POMEROY, MUSTAFA SAHIN · 2021 to 2026
$9.4MHuman Epilepsy Genetics Neuronal Migration DisordersR37NS035129 · NINDS · BOSTON CHILDREN'S HOSPITAL · PI Christopher A. Walsh · 2002 to 2026
$6.5MThe Role of RhoA in the Molecular Pathogenesis of Heart DiseaseR01HL102368 · NHLBI · MASONIC MEDICAL RESEARCH LABORATORY, INC · PI KONTARIDIS, MARIA I · 2010 to 2021
$5.1MRole of clonal somatic mutations in microglia and Alzheimer’s diseaseR01AG088082 · NIA · BOSTON CHILDREN'S HOSPITAL · PI Yue Huang · 2024 to 2026
$4.4MRole of transposon dysregulation in Alzheimer and aging brains revealed by single-cell genomic and transcriptomic analysisR01AG078929 · NIA · BOSTON CHILDREN'S HOSPITAL · PI Alice Eunjung Lee, Christopher A. Walsh · 2022 to 2026
$4.3MRates and mechanisms of age-related somatic mutation in normal and Alzheimer brainR01AG070921 · NIA · BOSTON CHILDREN'S HOSPITAL · PI LEE, ALICE EUNJUNG, WALSH, CHRISTOPHER A. · 2021 to 2025
$4.3MTargeted inhibition of fibrosis for the prevention of heart failureR01HL122238 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI MCCARTHY, JASON R. · 2015 to 2019
$4.0MIlluminating neurodegenerative tauopathy from somatic genomic landscapes of single human brain cellsDP2AG086138 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI Michael B Miller · 2023 to 2026
$2.7MMechanisms of Somatic Mutation in Alzheimer's Disease Using Single Neuron AnalysisR01AG082346 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI Michael B Miller · 2024 to 2026
$2.7MMechanism for endogenous retroelements to mimic ancient exogenous identities in aging and diseased human tissueDP2AG072437 · NIA · BOSTON CHILDREN'S HOSPITAL · PI LEE, EUNJUNG ALICE · 2020 to 2020
$2.7MModulation of Choroid Plexus Immuno-secretory Function to Restore Cerebrospinal Fluid Homeostasis in HydrocephalusR01NS109358 · NINDS · YALE UNIVERSITY · PI Kristopher T. Kahle · 2018 to 2026
$2.4MDoris Duke Charitable Foundation 2022032NHLBI NIH HHS R01 HL102368NHLBI NIH HHS R01 HL122238NIA NIH HHS DP2 AG072437NIA NIH HHS DP2 AG086138NIA NIH HHS R01 AG070921NIA NIH HHS R01 AG078929NIA NIH HHS R01 AG082346NIA NIH HHS R01 AG088082NIA NIH HHS R56 AG079857NICHD NIH HHS P50 HD105351NINDS NIH HHS K08 NS128272NINDS NIH HHS L30 NS118655NINDS NIH HHS R01 NS032457NINDS NIH HHS R01 NS109358NINDS NIH HHS R37 NS035129NINDS NIH HHS UG3 NS132138NINDS NIH HHS UG3 NS132144
Abstract
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.