SynthesisFrontiers in aging neuroscience2025
Effects of different types of deep brain stimulation on gait disorders in patients with Parkinson's disease: a network meta-analysis of randomized controlled trials.
Synthesis in Frontiers in aging neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To systematically compare and rank the relative efficacy of different types of deep brain stimulation (DBS) for gait disorders in patients with Parkinson's disease (PD), with particular emphasis on three outcomes: motor function (MDS-UPDRS III), Freezing of Gait Questionnaire (FOG-Q), and normal gait velocity (cm/s). The goal is to provide evidence-based guidance for individualized neuromodulation strategies. Methods: Following a preregistered protocol (PROSPERO CRD420251074368), a comprehensive literature search was conducted from January 1, 2000, to June 15, 2025, across PubMed, Embase, Cochrane Library, and CNKI. Randomized controlled trials (RCTs) meeting predefined PICOS criteria were included, and continuous outcome data for MDS-UPDRS III, FOG-Q and normal gait velocity in the Off-Dopa state were extracted. A frequentist network meta-analysis framework (R, netmeta package) was employed, with mean difference (MD) and 95% confidence intervals (CI) as effect estimates. Heterogeneity was quantified using Results: Twenty-five RCTs were included, involving 324 patients in intervention groups and 324 in control groups. (1) MDS-UPDRS III: Network meta-analysis showed that Low-PPNa-DBS produced the greatest improvement in motor function (MD = -31.20, 95% CI -53.25 to -9.15, Conclusion: This network meta-analysis systematically compared the effects of different DBS modalities on gait disorders in PD. For MDS-UPDRS Part III, Low-PPNa-DBS, PPN-DBS, and CuN-DBS yielded the most pronounced and statistically robust improvements. In contrast, analysis of FOG-Q scores revealed no statistically significant effects for any DBS intervention. Regarding gait speed, spDBS and STN-DBS showed clear and significant enhancements. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD420251074368, Identifier: CRD420251074368.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.