Evidence map›Paper›PMID 41659792›Full record

ArticleCell reports. Physical science2025

Reversal of the Leloir pathway to promote galactose and tagatose synthesis from glucose.

Aaron M Love, Christopher G Toomey, Abhishek Kumar, Sukesh Narayan Kashyap, Dhinesh Kumar Santhamoorthy, Likith Muthuraj, Hannah L Lynch, Parayil Kumaran Ajikumar, Kumar R Pravin, Nikhil U Nair and 1 more

Abstract read
In one paragraph

Article in Cell reports. Physical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Engineering ofCurrent research in food science · 2026
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Aaron M LoveManus Bio, Waltham, MA 02453, USA.
Christopher G ToomeyManus Bio, Waltham, MA 02453, USA.
Abhishek KumarKcat Enzymatic Pvt. Ltd., Bengaluru, Karnataka 560005, India.
Sukesh Narayan KashyapKcat Enzymatic Pvt. Ltd., Bengaluru, Karnataka 560005, India.
Dhinesh Kumar SanthamoorthyKcat Enzymatic Pvt. Ltd., Bengaluru, Karnataka 560005, India.
Likith MuthurajKcat Enzymatic Pvt. Ltd., Bengaluru, Karnataka 560005, India.
Hannah L LynchManus Bio, Waltham, MA 02453, USA.
Parayil Kumaran AjikumarManus Bio, Waltham, MA 02453, USA.
Kumar R PravinKcat Enzymatic Pvt. Ltd., Bengaluru, Karnataka 560005, India.
Nikhil U NairDepartment of Chemical & Biological Engineering, Tufts University, Medford, MA 02155, USA.
Christine N S SantosManus Bio, Waltham, MA 02453, USA.

Funding

Developing Synthetic Enzymes to Treat Inborn Errors of MetabolismR21HD105934 · NICHD · TUFTS UNIVERSITY MEDFORD · PI NAIR, NIKHIL UNNI · 2022 to 2023
$344k
NICHD NIH HHS R21 HD105934
6 · The paper itself

Abstract

D-Tagatose is a low-calorie rare sugar with health benefits as a low-glycemic sweetener. Current production methods are limited, often relying on galactose isomerization, and remain inefficient and costly. Here, we report a whole-cell process in

Identifiers

PMID41659792
PMCPMC12875667

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.