Evidence map›Paper›PMID 41660074›Full record

Trial reportPeerJ2026

Repetitive transcranial magnetic stimulation promotes the recovery of upper limb motor dysfunction in ischemic stroke patients: a DTI-based glymphatic system imaging prospective study.

Yulan Dong, Jing Liu, Tianyao Wang, Zhaoxiang Zhang, Xiaoyue Hu, Chengjia Zhu, Meijuan Gao, Ping Yan, Hao Lei, Jun Zhou

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PeerJ, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yulan Dong *Department of Radiology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
Jing Liu *Rehabilitation Medicine Center, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
Tianyao WangDepartment of Radiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Zhaoxiang ZhangDepartment of Radiology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
Xiaoyue HuDepartment of Radiology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
Chengjia ZhuDepartment of Radiology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
Meijuan GaoDepartment of Radiology, Changsha Hospital of Traditional Chinese Medicine (Changsha Eighth Hospital), Changsha, Hunan, China.
Ping YanDepartment of Radiology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
Hao LeiDepartment of Radiology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
Jun ZhouRehabilitation Medicine Center, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Repetitive transcranial magnetic stimulation (rTMS) is an effective tool for motor function recovery in patients with ischemic stroke (IS). Dysfunction of the glymphatic system is implicated in the pathological process of IS. However, it is still unclear whether the recovery of upper limb motor function in IS is affected by rTMS-driven modulation of glymphatic system function. This study aimed to investigate the potential utility of diffusion tensor imaging analysis along the perivascular space (DTI-ALPS) in assessing the impact of rTMS on IS recovery. Methods: This prospective study recruited IS participants with upper limb motor disorders. A total of 35 participants were randomly assigned to receive either low-frequency rTMS (LF-rTMS) or high-frequency rTMS (HF-rTMS) for two weeks. HF-rTMS was conducted on the infarcted hemisphere M1 and the LF-rTMS was conducted on the non-infarcted hemisphere M1. The information collected from each patient included clinical characteristics, upper limb motor function score, and bilateral hemisphere DTI-ALPS index. Paired Results: At baseline, no significant differences were observed in the DTI-ALPS index between the HF-rTMS and LF-rTMS groups. After two weeks of rTMS treatment, the DTI-ALPS index of the non-stimulated hemisphere in the HF-rTMS group significantly decreased ( Conclusion: Both HF-rTMS and LF-rTMS are beneficial for the rehabilitation of upper limb motor function in patients with IS, but the different changes in DTI-ALPS index may indicate differential effects of HF-rTMS and LF-rTMS on the glymphatic system. However, more research is needed to confirm the underlying mechanisms of this interaction.

Indexed as

Diffusion Tensor ImagingIschemic StrokeStroke RehabilitationTranscranial Magnetic StimulationUpper ExtremityAgedFemaleHumansMaleMiddle AgedProspective StudiesRecovery of FunctionDiffusion tensor image analysis along the perivascular spaceGlymphatic systemIschemic strokeRepetitive transcranial magnetic stimulationUpper limb motor dysfunction

Identifiers

PMID41660074
PMCPMC12880090

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.