Evidence map›Paper›PMID 41660117›Full record

ArticleMaterials today. Bio2026

Ultrasound-activated piezoelectric Silk-PVDF hydrogel reprograms the osteoimmune microenvironment via NRF2 signaling for accelerated bone regeneration.

Guokang Mo, Lang Qing, Cheng Zhang, Lei Huang, Hongze Yan, Shunyi Lu, Yongxin Zhang, Weisin Chen, Xingdong Xiang, Ning Wang and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Guokang MoDepartment of Rehabilitation Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
Lang QingThe Key Laboratory for Ultrafine Materials of Ministry of Education, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Engineering Research Center for Biomedical Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai, China.
Cheng ZhangDepartment of Rehabilitation Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
Lei HuangDivision of Spine, Department of Orthopedics, Tongji Hospital, Tongji University School of Medicine, Shanghai, China.
Hongze YanDepartment of Hand Surgery, Huashan Hospital, Fudan University, Shanghai, China.
Shunyi LuDepartment of Orthopedic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China.
Yongxin ZhangDepartment of Rehabilitation Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
Weisin ChenDepartment of Rehabilitation Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
Xingdong XiangDepartment of Rehabilitation Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
Ning WangDepartment of Rehabilitation Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
Guanjie HanDepartment of Rehabilitation Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
Yulin LiThe Key Laboratory for Ultrafine Materials of Ministry of Education, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Engineering Research Center for Biomedical Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai, China.
Libo JiangDepartment of Rehabilitation Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
Jian ZhangDepartment of Rehabilitation Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bone defects pose significant clinical challenges due to the limited regenerative capacity of adult bone and the shortcomings of existing biomaterials, which lack dynamic electromechanical signaling crucial for repair. Here, we present an injectable, ultrasound-responsive piezoelectric hydrogel engineered to synergize silk fibroin's (SF) structural adaptability with polyvinylidene fluoride's (PVDF) bioelectrical activity. Methacrylated silk fibroin (SM) enables rapid UV-triggered crosslinking via a cost-effective photoinitiator system, while electrospun PVDF nanofibers, cryosectioned into microscale units, confer dynamic piezoelectric responsiveness. Under ultrasound stimulation, PVDF generates localized electrical cues that transiently elevate reactive oxygen species (ROS), activating the NRF2 antioxidant pathway to resolve oxidative stress, which polarizes macrophages toward pro-regenerative M2 phenotypes, enhances osteogenic differentiation of adipose-derived mesenchymal stem cells (ADSCs) and promotes angiogenesis

Indexed as

Bone regenerationNRF2 signalingOsteoimmune microenvironmentPiezoelectric hydrogelUltrasound-responsive

Identifiers

PMID41660117
PMCPMC12874108

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.