Evidence map›Paper›PMID 41660125›Full record

ReviewMaterials today. Bio2026

Harnessing polysaccharide-mediated biomineralization for advanced bone tissue engineering.

Huxin Tang, Mingyang Hu, Xinying Huang, Jianan Chen, Yesheng Jin, Shuo Chen, Ke Li, Yong Xu

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Huxin TangDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College, Soochow University, Suzhou, Jiangsu, 215000, China.
Mingyang HuDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College, Soochow University, Suzhou, Jiangsu, 215000, China.
Xinying HuangDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College, Soochow University, Suzhou, Jiangsu, 215000, China.
Jianan ChenDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College, Soochow University, Suzhou, Jiangsu, 215000, China.
Yesheng JinDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College, Soochow University, Suzhou, Jiangsu, 215000, China.
Shuo ChenDepartment of Sports Medicine, Nanjing Hospital of Chinese Medicine affiliated to Nanjing University of Chinese Medicine, Nanjing, 210022, China.
Ke LiDepartment of Burn and Plastic Surgery, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, 215006, China.
Yong XuDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College, Soochow University, Suzhou, Jiangsu, 215000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biomineralization is a critical process wherein organisms form mineral composites via organic-inorganic synergistic interactions, which are essential for maintaining and repairing bone tissue homeostasis. Polysaccharides, as a class of natural biological macromolecules, play a crucial role in regulating biomineralization processes. This may be ascribed to their distinctive physical and chemical characteristics, in addition to their biological functions. These molecules effectively alter the crystalline structure and mechanical attributes of minerals like hydroxyapatite by adjusting ion levels, supplying sites for nucleation during mineral formation, and interacting with other biomolecules such as collagen to direct the deposition of minerals. Chitosan, alginate, hyaluronic acid, and sulfated polysaccharides have shown significant biomimetic properties through the creation of biomimetic scaffolds, improvement of cell attachment and differentiation, and facilitation of bone defect healing. This article systematically reviews the molecular mechanisms of polysaccharides in biomineralization and discusses their applications in bone tissue engineering from a biomineralization perspective, thereby offering novel insights for clinical treatment.

Indexed as

BiomineralizationBone tissue engineeringHydroxyapatitePolysaccharideRegulation of mineralization

Identifiers

PMID41660125
PMCPMC12874333

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.