ArticleHuman mutation2026
Causal Relationships Between Plasma Metabolites, Inflammatory Factors, and Oral Cancer Risk: A Comprehensive Mendelian Randomization Study With Mediation Analysis.
Article in Human mutation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study conducted a large-scale Mendelian randomization analysis using genome-wide single nucleotide polymorphisms (SNPs) as instrumental variables to investigate the causal relationships between 1400 circulating metabolites and oral cancer risk. The genetic data were derived from the Canadian Longitudinal Study on Aging (CLSA) cohort and the IEU OpenGWAS database. The study employed germline genetic variants captured in genome-wide association studies for causal inference, combined with mediation analysis and CAL-27 cell experimental validation. The results identified 61 metabolites with significant causal relationships with oral cancer through SNP instrumental variables (29 with protective effects and 32 increasing risk) and revealed 14 inflammatory factors as key mediating variables, with mediation effects accounting for 1.4%-17.4% of the total effects. Cell experiments further confirmed that aspartate significantly downregulates CCL11 expression and secretion and exerts anti-inflammatory effects by suppressing inflammatory factors, including IL-1
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