ReviewBone reports2026
The effect of spaceflight on tissues of the spinal column.
Review in Bone reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The unique mechanical unloading induced by spaceflight is associated with a very high incidence rate of chronic back pain and general degradation of tissues associated with the spinal column (i.e., bone, skeletal muscle, intervertebral disc, and cartilage). Despite the well documented phenomena of spinal damage following microgravity conditions, there is not a clear timeline of the pathways that leads to bulk tissue damage and back pain. This is both due to the majority of work in the field focusing on assessing the impact of microgravity on a single component or tissue, as well as in doing so at a narrow scale (e.g., genetic, cellular, morphologic, etc.). This review paper surveyed the literature to assemble a multiscale timeline for the pathway of degeneration due to mechanical unloading for key tissues of the spinal column. In doing so, we aim to clarify the cascading, multiscale, degenerative pathway caused by spaceflight conditions that manifest into bulk tissue atrophy and pain. This work also covers potential avenues of investigation to mitigate the deleterious effects of prolonged mechanical unloading on the spine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.