Evidence map›Paper›PMID 41660786›Full record

ArticlePlant biotechnology journal2026

CpERF-WRI1 Manipulates Ethylene Sensing by Regulating the Expression of CpERS1 and Fruit Ripening in Papaya.

Ziling Wu, Jiahui Cai, Faiz Ur Rahman, Wang Zheng, Qiunan Zhu, Weixin Chen, Xueping Li, Xiaoyang Zhu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Plant biotechnology journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ziling WuGuangdong Provincial Key Laboratory of Postharvest Science of Fruits and Vegetables/Engineering Research Center for Postharvest Technology of Horticultural Crops in South China, Ministry of Education, College of Horticulture, South China Agricultural University, Guangzhou, Guangdong, China.
Jiahui CaiGuangdong Provincial Key Laboratory of Postharvest Science of Fruits and Vegetables/Engineering Research Center for Postharvest Technology of Horticultural Crops in South China, Ministry of Education, College of Horticulture, South China Agricultural University, Guangzhou, Guangdong, China.
Faiz Ur RahmanGuangdong Provincial Key Laboratory of Postharvest Science of Fruits and Vegetables/Engineering Research Center for Postharvest Technology of Horticultural Crops in South China, Ministry of Education, College of Horticulture, South China Agricultural University, Guangzhou, Guangdong, China.
Wang ZhengGuangdong Provincial Key Laboratory of Postharvest Science of Fruits and Vegetables/Engineering Research Center for Postharvest Technology of Horticultural Crops in South China, Ministry of Education, College of Horticulture, South China Agricultural University, Guangzhou, Guangdong, China.
Qiunan ZhuGuangdong Provincial Key Laboratory of Postharvest Science of Fruits and Vegetables/Engineering Research Center for Postharvest Technology of Horticultural Crops in South China, Ministry of Education, College of Horticulture, South China Agricultural University, Guangzhou, Guangdong, China.
Weixin ChenGuangdong Provincial Key Laboratory of Postharvest Science of Fruits and Vegetables/Engineering Research Center for Postharvest Technology of Horticultural Crops in South China, Ministry of Education, College of Horticulture, South China Agricultural University, Guangzhou, Guangdong, China.
Xueping LiGuangdong Provincial Key Laboratory of Postharvest Science of Fruits and Vegetables/Engineering Research Center for Postharvest Technology of Horticultural Crops in South China, Ministry of Education, College of Horticulture, South China Agricultural University, Guangzhou, Guangdong, China.
Xiaoyang ZhuGuangdong Provincial Key Laboratory of Postharvest Science of Fruits and Vegetables/Engineering Research Center for Postharvest Technology of Horticultural Crops in South China, Ministry of Education, College of Horticulture, South China Agricultural University, Guangzhou, Guangdong, China.

Funding

Modern Agricultural Industry Technology System Innovation Team Construction Project of Guangdong Province 2024CXTD09National Key Research and Development Program of China 2022YFD2100102National Natural Science Foundation of China 32172640
6 · The paper itself

Abstract

Ethylene plays a crucial role in fruit ripening and is perceived by specialised receptor proteins embedded in the endoplasmic reticulum (ER) membrane. As an ethylene antagonist, 1-methylcyclopropene (1-MCP) binds to these receptors and delays papaya ripening, but improper use can cause ripening disorders. The expression of CpERS1 and CpERF-WRI1 is markedly upregulated during ripening yet is suppressed by inappropriate 1-MCP treatments. Similar ripening disorders and expression patterns of CpERS1 and CpERF-WRI1 were observed in immature, chilled and heat-stressed papaya fruits, indicating that these genes may play key roles in ripening disorder. CpERF-WRI1 binds to and activates the CpERS1 promoter both in vitro and in vivo. Transient overexpression of CpERF-WRI1 in papaya and ectopic expression in tomato accelerated fruit ripening, increased CpERS1 expression and upregulated ripening-related pathways, whereas virus-induced gene silencing (VIGS) of CpERF-WRI1 in papaya delayed ripening and downregulated those pathways. Similarly, overexpressing CpERS1 in papaya and tomato accelerated ripening and boosted the expression of ripening-associated genes, while VIGS-mediated silencing of CpERS1 delayed ripening and suppressed these genes. Together, these results indicate that CpERF-WRI1 regulates CpERS1 expression and modulates ethylene sensing within the system II ethylene signalling pathway to control papaya ripening.

Indexed as

CaricaEthylenesFruitGene Expression Regulation, PlantPlant ProteinsCyclopropanesGene SilencingPlants, Genetically ModifiedPromoter Regions, GeneticSignal TransductionSolanum lycopersicum1-methylcyclopropeneCyclopropanesethyleneEthylenesPlant ProteinsCpERF‐WRI1CpERS1ethyleneethylene receptorethylene sensingfruit ripeningpapaya

Identifiers

PMID41660786
PMCPMC13205678

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.