Evidence map›Paper›PMID 41661118›Full record

ArticleGastroenterology2026

Genomic Insights Into Inflammatory Bowel Disease in United States Hispanic Participants: An Ancestry-Focused Study.

Ashley H Beecham, Dermot P B McGovern, Steven W Brugger, Mary F Davis, Esther A Torres, Lissette Gomez, Dalin Li, Paola Lopez-Marte, Mark J Daly, Christine Stevens and 14 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gastroenterology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Ashley H BeechamDepartment of Biostatistics and Data Science, Wake Forest University School of Medicine, Winston Salem, North Carolina; John P. Hussman Institute for Human Genomics, University of Miami School of Medicine, Miami, Florida. Electronic address: ashley.beecham@advocatehealth.org.
Dermot P B McGovernF. Widjaja Inflammatory Bowel Disease Institute, Cedars-Sinai Medical Center, Los Angeles, California.
Steven W BruggerDepartment of Microbiology and Molecular Biology, Brigham Young University, Provo, Utah.
Mary F DavisDepartment of Microbiology and Molecular Biology, Brigham Young University, Provo, Utah.
Esther A TorresUniversity of Puerto Rico School of Medicine, San Juan, Puerto Rico.
Lissette GomezJohn P. Hussman Institute for Human Genomics, University of Miami School of Medicine, Miami, Florida.
Dalin LiF. Widjaja Inflammatory Bowel Disease Institute, Cedars-Sinai Medical Center, Los Angeles, California.
Paola Lopez-MarteUniversity of Puerto Rico School of Medicine, San Juan, Puerto Rico.
Mark J DalyBroad Institute, Boston, Massachusetts; Institute of Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.
Christine StevensBroad Institute, Boston, Massachusetts.
Shaohong YangF. Widjaja Inflammatory Bowel Disease Institute, Cedars-Sinai Medical Center, Los Angeles, California.
Sweta SinhaF. Widjaja Inflammatory Bowel Disease Institute, Cedars-Sinai Medical Center, Los Angeles, California.
Emebet MengeshaF. Widjaja Inflammatory Bowel Disease Institute, Cedars-Sinai Medical Center, Los Angeles, California.
James LeavittGastro-health, Miami, Florida.
Oriana M DamasDivision of Digestive Health and Liver Diseases, University of Miami Leonard Miller School of Medicine, Miami, Florida.
Maria A QuinteroF. Widjaja Inflammatory Bowel Disease Institute, Cedars-Sinai Medical Center, Los Angeles, California.
Stephan R TarganF. Widjaja Inflammatory Bowel Disease Institute, Cedars-Sinai Medical Center, Los Angeles, California.
Shervin RabizadehF. Widjaja Inflammatory Bowel Disease Institute, Cedars-Sinai Medical Center, Los Angeles, California.
Ksenija SabicDepartment of Pathology, Molecular and Cell-based Therapy, Icahn School of Medicine at Mount Sinai, New York, New York.
NIDDK IBD Genetics Consortium
Judy H ChoDepartment of Pathology, Molecular and Cell-based Therapy, Icahn School of Medicine at Mount Sinai, New York, New York.
Maria T AbreuF. Widjaja Inflammatory Bowel Disease Institute, Cedars-Sinai Medical Center, Los Angeles, California; UHealth Crohn's and Colitis Center, Division of Gastroenterology, Department of Medicine, University of Miami School of Medicine, Miami, Florida.
Jacob L McCauleyJohn P. Hussman Institute for Human Genomics, University of Miami School of Medicine, Miami, Florida.
Talin HarituniansF. Widjaja Inflammatory Bowel Disease Institute, Cedars-Sinai Medical Center, Los Angeles, California. Electronic address: talin.haritunians@cshs.org.

Funding

Large Scale Sequencing and Analysis of GenomesU54HG003067 · NHGRI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GABRIEL, STACEY, LANDER, ERIC S · 2004 to 2015
$568.6M
Center for Common Disease GeneticsUM1HG008895 · NHGRI · BROAD INSTITUTE, INC. · PI DALY, MARK JOSEPH, GABRIEL, STACEY · 2016 to 2020
$111.2M
Precision IBD via genetics and genomics: integrating International and multi-omic datasets, expanding studies in diverse populations, and defining mechanisms of unmet clinical needs in IBDU24DK062429 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Ling-shiang Chuang, Ron Do · 2017 to 2026
$13.9M
Utilizing the Phenomics of IBD to Enhance Gene DiscoveryU01DK062413 · NIDDK · CEDARS-SINAI MEDICAL CENTER · PI Dermot Patrick McGovern · 2002 to 2026
$12.2M
Yale University Inflammatory Bowel Disease Genetics Research CenterU01DK062422 · NIDDK · YALE UNIVERSITY · PI Ling-shiang Chuang · 2002 to 2026
$10.8M
IBD Gene Mapping by Clinical and Population SubsetsU01DK062431 · NIDDK · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI Steven R Brant · 2002 to 2026
$10.7M
Universite de Montreal IBD Genetics Research CenterU01DK062432 · NIDDK · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI John D. Rioux · 2002 to 2026
$9.6M
University of Miami Federated Biorepository Facility to Advance Biomedical ResearchC06OD030170 · OD · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI MCCAULEY, JACOB L · 2020 to 2020
$7.6M
Impact of Genetic Variability on Cellular Pathways and Host-Microbiome InteractioU01DK062423 · NIDDK · SINAI HEALTH SYSTEM · PI MARK S. SILVERBERG · 2002 to 2026
$7.5M
University of Miami IBD Genetic Research Center: Understanding the Genetic Architecture of IBD in the South Florida communityU01DK134201 · NIDDK · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Maria Teresa Abreu, Jacob L McCauley · 2022 to 2026
$3.0M
The impact of diet patterns and PUFA-related polymorphisms on ulcerative colitis in HispanicsK23DK117054 · NIDDK · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI DAMAS, ORIANA MAZORRA · 2019 to 2023
$1.0M
HISPANIC COMMUNITY HEALTH STUDY-268065233N01HC065233 · HC · COORDINATING CENTER · PI CHAMBLESS, LLOYD E · 2006 to 2006
–
NHGRI NIH HHS U54 HG003067NHGRI NIH HHS UM1 HG008895NHLBI NIH HHS N01 HC065233NHLBI NIH HHS N01 HC065234NHLBI NIH HHS N01 HC065235NHLBI NIH HHS N01 HC065236NHLBI NIH HHS N01 HC065237NIDDK NIH HHS K23 DK117054NIDDK NIH HHS U01 DK062413NIDDK NIH HHS U01 DK062422NIDDK NIH HHS U01 DK062423NIDDK NIH HHS U01 DK062431NIDDK NIH HHS U01 DK062432NIDDK NIH HHS U01 DK134201NIDDK NIH HHS U24 DK062429NIH HHS C06 OD030170
6 · The paper itself

Abstract

BACKGROUND &

aimsGenetic admixture of United States Hispanic individuals provides a unique opportunity to examine ancestral origins of inflammatory bowel disease (IBD) risk. In ∼7.3K Hispanic participants (1660 IBD cases; 5614 controls), we examined ancestral heterogeneity of IBD clinical phenotypes and sought to identify IBD risk loci that displayed heterogeneity of effect or were ancestry-specific.

methodsAssociation of genetic ancestry with clinical phenotypes was evaluated. We conducted an ancestry-informed genome-wide (GW) association study for IBD, ulcerative colitis, and Crohn's disease (CD) to obtain ancestry-specific effect size estimates for alleles from African (AFR), European (EUR), and Amerindian (AIAN) origin. Ancestry-specific replication was assessed in All of Us Hispanic participants and transferability was evaluated for populations with similar ancestral origin.

resultsClinical phenotypes were associated with higher AFR (colonic, penetrating, or perianal CD; later age at diagnosis; IBD-related surgery) or AIAN ancestry (colonic CD). GW EUR-specific associations were observed within established loci for CD (NOD2, IL23R, HLA-DRA) and ulcerative colitis (HLA locus). For AFR or AIAN alleles, novel GW associations were observed in 14 loci. One AFR-specific IBD GW (PCGEM1) and 2 AFR-specific suggestive (TYROBP/LRFN3) associations replicated in All of Us. Several suggestive associations demonstrated transferability (AFR-specific TYROBP/LRFN3 and AIAN-specific GAD2). Several novel IBD risk variants also demonstrated association with clinical phenotypes.

conclusionsAncestry-informed regression enabled identification of novel AFR and AIAN-specific risk alleles, which may also inform observed phenotypic differences. We have shown that some previously identified IBD loci have associations that are EUR-specific. These findings highlight the importance of genetic ancestry for elucidating the biological underpinnings of IBD and may have important pharmacogenetic implications.

Indexed as

Colitis, UlcerativeCrohn DiseaseHispanic or LatinoInflammatory Bowel DiseasesAdultAmerican Indian or Alaska NativeBlack or African AmericanCase-Control StudiesEuropean PeopleFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMaleMiddle AgedPhenotypeAncestryDiversityGeneticsHispanicInflammatory Bowel Disease

Identifiers

PMID41661118
PMCPMC13140159

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.