SynthesisCalcified tissue international2026
Understanding Bone Metabolism Biomarker Variability Across the Menstrual Cycle: A Systematic Review.
Synthesis in Calcified tissue international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Biochemical Responses to Experimentally Induced Short-Term Low Energy Availability in Athletes: A Systematic Review.Scandinavian journal of medicine & science in sports · 2026Pooled it
- Greek Yogurt Compared with Whey Protein Supplementation in Adolescent Athletes Throughout a Competitive Season.The Journal of nutrition · 2026Trial
- Gender- and Age-Related Changes in the Spectrum of the Differentiation Potential of Individual Colonies of Stromal Precursors from Human Bone Marrow.International journal of molecular sciences · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bone metabolism is a dynamic process regulated by systemic and local factors, including sex hormones. While in vitro studies suggest that hormonal fluctuations impact bone biomarkers, in vivo findings remain inconsistent. Therefore, this systematic review aimed to evaluate whether biochemical markers of bone resorption and bone formation fluctuate across different phases of the menstrual cycle in healthy regular menstruating females. Following PRISMA guidelines, a comprehensive search was conducted in PubMed and Web of Science (January 2025). A total of 18 studies were included and assessed for quality using the NHLBI Quality Assessment Tool. Considerable heterogeneity was found across studies in design, phase classification, and outcome reporting. While 5 out of 7 studies on β-CTX-I reported lower concentrations during the luteal phase, 6 out of 8 studies showed that osteocalcin concentrations did not vary across the MC. Findings concerning other biomarkers included in this review were limited and inconsistent, hindering the identification of a clear trend. Current evidence does not establish a consistent pattern in bone metabolism biomarker fluctuations across the MC. Variability in methodology, hormone verification, and participant characteristics may contribute to these inconsistencies.PROSPERO registration CRD42022375821.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.